α-gal A Activators
The chemical class of α-gal A Activators includes compounds that can indirectly influence α-gal A function through their effects on enzyme stabilization, lysosomal function, and cellular stress responses. α-gal A is crucial for the degradation of glycolipids in lysosomes, and its dysfunction is central to the pathophysiology of Fabry disease. Compounds like Migalastat and Deoxygalactonojirimycin function as pharmacological chaperones, stabilizing the structure of α-gal A and potentially enhancing its activity. These compounds directly interact with the enzyme, facilitating proper folding and stabilization, which can increase its functional activity.
Substances like Genistein, Ambroxol, and Epigallocatechin Gallate (EGCG) have been suggested to influence α-gal A activity through various mechanisms, including enzyme stabilization and modulation of cellular pathways. For instance, EGCG's potential stabilizing effect on lysosomal enzymes could indirectly enhance α-gal A activity. Additionally, compounds that influence gene expression and cellular stress responses, such as 4-Phenylbutyrate, Curcumin, and Resveratrol, could indirectly affect α-gal A function. These compounds might impact the cellular environment and stress pathways, thereby modulating the activity of enzymes like α-gal A.
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
D-Galactose | 59-23-4 | sc-202564 | 100 g | $288.00 | 4 | |
As a substrate analog, it might influence α-gal A folding and stability, potentially enhancing its activity. | ||||||
Genistein | 446-72-0 | sc-3515 sc-3515A sc-3515B sc-3515C sc-3515D sc-3515E sc-3515F | 100 mg 500 mg 1 g 5 g 10 g 25 g 100 g | $45.00 $164.00 $200.00 $402.00 $575.00 $981.00 $2031.00 | 46 | |
A tyrosine kinase inhibitor; suggested to increase α-gal A activity in some cellular models. | ||||||
Ambroxol hydrochloride | 23828-92-4 | sc-200816 | 1 g | $55.00 | ||
A mucolytic agent; shown to enhance α-gal A activity in some studies. | ||||||
(−)-Epigallocatechin Gallate | 989-51-5 | sc-200802 sc-200802A sc-200802B sc-200802C sc-200802D sc-200802E | 10 mg 50 mg 100 mg 500 mg 1 g 10 g | $43.00 $73.00 $126.00 $243.00 $530.00 $1259.00 | 11 | |
Found in green tea; suggested to have a stabilizing effect on lysosomal enzymes, including α-gal A. | ||||||
Sodium phenylbutyrate | 1716-12-7 | sc-200652 sc-200652A sc-200652B sc-200652C sc-200652D | 1 g 10 g 100 g 1 kg 10 kg | $77.00 $166.00 $622.00 $5004.00 $32783.00 | 43 | |
A histone deacetylase inhibitor; could influence gene expression and potentially α-gal A activity. | ||||||
Curcumin | 458-37-7 | sc-200509 sc-200509A sc-200509B sc-200509C sc-200509D sc-200509F sc-200509E | 1 g 5 g 25 g 100 g 250 g 1 kg 2.5 kg | $37.00 $69.00 $109.00 $218.00 $239.00 $879.00 $1968.00 | 47 | |
Known for anti-inflammatory properties; might influence cellular pathways affecting α-gal A. | ||||||
Quercetin | 117-39-5 | sc-206089 sc-206089A sc-206089E sc-206089C sc-206089D sc-206089B | 100 mg 500 mg 100 g 250 g 1 kg 25 g | $11.00 $17.00 $110.00 $250.00 $936.00 $50.00 | 33 | |
An antioxidant, potentially influencing cellular stress pathways and α-gal A activity. | ||||||
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $80.00 $220.00 $460.00 | 64 | |
Affects sirtuin pathways, potentially modulating cellular processes including α-gal A activity. | ||||||