ALDH3B2 Activators

ALDH3B2 activators encompass a collection of compounds that can, either directly or indirectly, stimulate the enzymatic function of ALDH3B2, a specific isoenzyme within the aldehyde dehydrogenase family. One fundamental compound is NAD+, an indispensable cofactor that elevates the activity of ALDH enzymes by facilitating the oxidation of aldehydes.

Compounds like Sulforaphane and Alda-1 have been documented to upregulate various ALDH isoforms, suggesting an influence on ALDH3B2. In contrast, agents like Retinoic acid work more covertly, modulating ALDH activity at the transcriptional level, possibly influencing ALDH3B2. The relationship between aldehyde dehydrogenase enzymes and certain phytochemicals is also noteworthy. For instance, Resveratrol, Curcumin, and Genistein have shown interactions with ALDHs through various cellular pathways, suggesting a modulation of ALDH3B2. The connection of ALDH activity to broader cellular signaling pathways is also highlighted by compounds like Forskolin, which operates via the cAMP pathway. The diverse nature of these activators underlines the complex regulatory landscape governing ALDH3B2's function within the cell.