Date published: 2025-10-28

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Agrin Inhibitors

Agrin inhibitors belong to a specific class of chemical compounds that are primarily designed to target and modulate the activity of agrin, a crucial protein in the neuromuscular system. Agrin is a large proteoglycan molecule that plays a pivotal role in the formation and maintenance of neuromuscular junctions (NMJs), which are specialized synapses connecting motor neurons and muscle fibers. These junctions are fundamental for transmitting electrical signals from motor neurons to muscle fibers, ultimately leading to muscle contraction. Agrin, in particular, is responsible for initiating the clustering of acetylcholine receptors (AChRs) at the postsynaptic membrane of muscle fibers, ensuring proper neuromuscular communication. Agrin inhibitors are designed to interfere with the function of agrin, often by binding to it or its receptor molecules. By doing so, they can disrupt the signaling cascades that lead to AChR clustering and synaptic maintenance. This disruption can have profound effects on neuromuscular function, making agrin inhibitors of interest in various research areas, particularly in understanding the molecular mechanisms underlying neuromuscular development and plasticity. Additionally, agrin inhibitors have applications in studies related to muscle diseases, motor neuron disorders, and synaptic plasticity.

Items 1 to 10 of 11 total

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Product NameCAS #Catalog #QUANTITYPriceCitationsRATING

Rapamycin

53123-88-9sc-3504
sc-3504A
sc-3504B
1 mg
5 mg
25 mg
$62.00
$155.00
$320.00
233
(4)

Rapamycin, an mTOR inhibitor, affects protein synthesis and cell growth. It could potentially inhibit Agrin expression as part of its broader impact on cellular regulatory pathways.

Dexamethasone

50-02-2sc-29059
sc-29059B
sc-29059A
100 mg
1 g
5 g
$76.00
$82.00
$367.00
36
(1)

Dexamethasone, a synthetic glucocorticoid, impacts various cellular processes, including inflammation and immune response. It may downregulate Agrin expression indirectly through its anti-inflammatory effects.

Curcumin

458-37-7sc-200509
sc-200509A
sc-200509B
sc-200509C
sc-200509D
sc-200509F
sc-200509E
1 g
5 g
25 g
100 g
250 g
1 kg
2.5 kg
$36.00
$68.00
$107.00
$214.00
$234.00
$862.00
$1968.00
47
(1)

Curcumin, a compound found in turmeric, has various biological activities. It may influence Agrin expression indirectly through its anti-inflammatory and antioxidant properties.

Resveratrol

501-36-0sc-200808
sc-200808A
sc-200808B
100 mg
500 mg
5 g
$60.00
$185.00
$365.00
64
(2)

Resveratrol, found in grapes and berries, has been studied for its antioxidant and anti-inflammatory properties. It could potentially influence Agrin expression as part of its broader effects on cellular health.

Quercetin

117-39-5sc-206089
sc-206089A
sc-206089E
sc-206089C
sc-206089D
sc-206089B
100 mg
500 mg
100 g
250 g
1 kg
25 g
$11.00
$17.00
$108.00
$245.00
$918.00
$49.00
33
(2)

Quercetin, a flavonoid found in many plants, exhibits antioxidant and anti-inflammatory activities. Its potential to modulate Agrin expression may be linked to these properties.

hydroxychloroquine

118-42-3sc-507426
5 g
$56.00
1
(0)

Hydroxychloroquine Sulfate can affect lysosomal function. It may have potential indirect effects on Agrin expression through its impact on cellular pathways.

(−)-Epigallocatechin Gallate

989-51-5sc-200802
sc-200802A
sc-200802B
sc-200802C
sc-200802D
sc-200802E
10 mg
50 mg
100 mg
500 mg
1 g
10 g
$42.00
$72.00
$124.00
$238.00
$520.00
$1234.00
11
(1)

(-)-Epigallocatechin Gallate, a major component of green tea, has antioxidant and anti-inflammatory properties. It could potentially influence Agrin expression as part of its broader effects on cell signaling and inflammation.

D,L-Sulforaphane

4478-93-7sc-207495A
sc-207495B
sc-207495C
sc-207495
sc-207495E
sc-207495D
5 mg
10 mg
25 mg
1 g
10 g
250 mg
$150.00
$286.00
$479.00
$1299.00
$8299.00
$915.00
22
(1)

Sulforaphane, found in cruciferous vegetables, exhibits antioxidant and anti-inflammatory activities. Its potential role in Agrin expression modulation may be related to these properties.

Aspirin

50-78-2sc-202471
sc-202471A
5 g
50 g
$20.00
$41.00
4
(1)

Aspirin affects cyclooxygenase enzymes and inflammation. It could potentially modulate Agrin expression indirectly through its anti-inflammatory effects.

1,1-Dimethylbiguanide, Hydrochloride

1115-70-4sc-202000F
sc-202000A
sc-202000B
sc-202000C
sc-202000D
sc-202000E
sc-202000
10 mg
5 g
10 g
50 g
100 g
250 g
1 g
$20.00
$42.00
$62.00
$153.00
$255.00
$500.00
$30.00
37
(1)

1,1-Dimethylbiguanide, Hydrochloride influences various metabolic pathways. Its potential to modulate Agrin expression may be linked to its broader effects on cellular metabolism and growth.