ADK Activators

The chemical class of ADK activators consists of a diverse range of compounds that indirectly influence the activity of Adenosine Kinase through various pathways related to nucleotide metabolism. These activators, which include both nucleotide analogs and drugs affecting nucleotide synthesis pathways, highlight the complex interplay between nucleotide metabolism and the regulation of key enzymes like ADK.

Compounds such as adenosine, methotrexate, and ribavirin are notable in this class for their roles in influencing nucleotide pools and metabolism. Adenosine, being a substrate of ADK, can lead to increased ADK activity as a compensatory response to high intracellular levels. Methotrexate and ribavirin, through their impact on purine and pyrimidine metabolism, can indirectly lead to alterations in ADK activity. These compounds demonstrate how changes in nucleotide synthesis and availability can indirectly modulate enzyme activities within the same metabolic pathway. Immunosuppressants and chemotherapy agents like mycophenolate mofetil, azathioprine, and clofarabine also play a significant role in this class. By impacting nucleotide synthesis pathways, these drugs can lead to changes in the nucleotide pool balance, influencing ADK activity. This indirect modulation underscores the complexity of nucleotide metabolism regulation.