ADH4 Inhibitors
ADH4 inhibitors span a range of structural classes and mechanisms, but a common theme among these compounds is their ability to competitively inhibit the enzymatic action. For example, 4-Methylpyrazole and Fomepizole directly compete with the native substrates by binding to the enzyme's active site, effectively decreasing ADH4's ability to catalyze the conversion of alcohols to aldehydes or ketones. These inhibitors essentially lock the enzyme in an inactive form by blocking its active site, thus providing a direct mechanism of inhibition. Others like Daidzin, Quercetin, and Gallic Acid employ similar mechanisms.
While some compounds directly inhibit ADH4, others like Disulfiram and Cyanamide work indirectly by affecting other enzymes in the alcohol metabolism pathway. For instance, they inhibit aldehyde dehydrogenase and contribute to acetaldehyde build-up, which in turn can inhibit ADH4. Another layer of complexity is added by compounds like Naloxone and Indomethacin, which can indirectly affect ADH4 through entirely different pathways such as opioid signaling and prostaglandin synthesis. These compounds underline the versatility in ADH4 inhibition, ranging from direct competition at the active site to indirect interference through related pathways.
Items 1 to 10 of 11 total
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Disulfiram | 97-77-8 | sc-205654 sc-205654A | 50 g 100 g | $52.00 $87.00 | 7 | |
It inhibits aldehyde dehydrogenase and has a secondary effect on ADH4. Inhibition of aldehyde dehydrogenase increases acetaldehyde concentration, which can indirectly inhibit ADH4 activity. | ||||||
Fomepizole | 7554-65-6 | sc-252838 | 1 g | $74.00 | 1 | |
Similar to 4-Methylpyrazole, Fomepizole competitively inhibits ADH4 by blocking the active site. | ||||||
Cyanamide | 420-04-2 | sc-239592 sc-239592A | 5 g 25 g | $21.00 $77.00 | ||
Known to inhibit aldehyde dehydrogenase, but also affects ADH4 by contributing to acetaldehyde build-up, which indirectly inhibits ADH4. | ||||||
Daidzin | 552-66-9 | sc-202123 sc-202123A | 1 mg 5 mg | $71.00 $134.00 | 1 | |
An isoflavone that inhibits alcohol dehydrogenases including ADH4, it blocks the enzyme's active site. | ||||||
Quercetin | 117-39-5 | sc-206089 sc-206089A sc-206089E sc-206089C sc-206089D sc-206089B | 100 mg 500 mg 100 g 250 g 1 kg 25 g | $11.00 $17.00 $108.00 $245.00 $918.00 $49.00 | 33 | |
Inhibits the ADH family by acting as a competitive inhibitor. It binds to the active site, thus preventing ADH4 from converting alcohol substrates to aldehydes. | ||||||
Caffeic Acid | 331-39-5 | sc-200499 sc-200499A | 1 g 5 g | $31.00 $61.00 | 1 | |
A polyphenol that inhibits alcohol dehydrogenase activity including ADH4. It achieves this through active site blockade. | ||||||
Naloxone | 465-65-6 | sc-477809 | 200 mg | $300.00 | 5 | |
Though mainly an opioid receptor antagonist, it indirectly inhibits ADH4 by modulating cAMP levels which can affect ADH4's enzymatic activity. | ||||||
Indomethacin | 53-86-1 | sc-200503 sc-200503A | 1 g 5 g | $28.00 $37.00 | 18 | |
An NSAID that can inhibit prostaglandin synthesis, a pathway that may indirectly affect ADH4 activity through cellular signaling. | ||||||
Gallic acid | 149-91-7 | sc-205704 sc-205704A sc-205704B | 10 g 100 g 500 g | $55.00 $85.00 $240.00 | 14 | |
Inhibits ADH family by competitive inhibition. It prevents ADH4 from converting its substrates by occupying the active site. | ||||||
D,L-Sulforaphane | 4478-93-7 | sc-207495A sc-207495B sc-207495C sc-207495 sc-207495E sc-207495D | 5 mg 10 mg 25 mg 1 g 10 g 250 mg | $150.00 $286.00 $479.00 $1299.00 $8299.00 $915.00 | 22 | |
An isothiocyanate that inhibits ADH family by non-competitive inhibition, it allosterically affects ADH4 preventing the enzyme from achieving an active conformation. | ||||||