ADH4 Activators
The ADH4 protein plays a pivotal role in metabolic pathways, especially in the oxidation of alcohols and the processing of various other substrates. Chemicals that interact with ADH4 can be broadly classified into direct substrates and indirect metabolic influencers. Ethanol, for instance, is directly metabolized by ADH4, converting it to acetaldehyde, a process that inherently upregulates the enzyme's activity. Similarly, butanol and isopropanol serve as substrates, indicating their direct role in promoting ADH4 activity. Chlorzoxazone and DEET are other notable compounds metabolized by ADH4, further emphasizing the diversity of substrates this enzyme can process.
On the other hand, compounds like NAD+, an essential cofactor, facilitate the enzymatic function of ADH4. Without NAD+, ADH4's oxidizing ability would be compromised. Another angle of interaction is through indirect metabolic influence, as seen with AICAR's activation of AMPK. By pushing cellular metabolism towards catabolism, ADH4's metabolic activity can be amplified. Acetate and pyruvate, both central to cellular metabolism, can also sway ADH4's activity. Acetate's conversion to acetyl-CoA can elevate the demand for ethanol metabolism, indirectly impacting ADH4 activity. Zinc, vital for ADH4's structural integrity, further cements its place as a significant influencer. Together, these chemicals showcase a mix of direct and indirect modulation of ADH4, each contributing uniquely to the enzyme's function within the cell.
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
NAD+, Free Acid | 53-84-9 | sc-208084B sc-208084 sc-208084A sc-208084C sc-208084D sc-208084E sc-208084F | 1 g 5 g 10 g 25 g 100 g 1 kg 5 kg | $56.00 $186.00 $296.00 $655.00 $2550.00 $3500.00 $10500.00 | 4 | |
NAD+ acts as a cofactor for ADH4. Its presence is crucial for the enzymatic activity of ADH4. Elevated NAD+ concentrations can enhance the substrate affinity and turnover rate of ADH4. | ||||||
Acetic acid | 64-19-7 | sc-214462 sc-214462A | 500 ml 2.5 L | $62.00 $104.00 | 5 | |
Acetate can be converted to acetyl-CoA, which can indirectly increase the demand for ethanol metabolism. This can potentially enhance ADH4's enzymatic activity. | ||||||
Pyruvic acid | 127-17-3 | sc-208191 sc-208191A | 25 g 100 g | $40.00 $94.00 | ||
Pyruvate, a product of glycolysis, can indirectly increase ADH4 activity by pushing the cellular metabolism towards ethanol breakdown, feeding into the Krebs cycle. | ||||||
Chlorzoxazone | 95-25-0 | sc-211078 | 10 mg | $61.00 | ||
This drug is metabolized by ADH enzymes including ADH4. In its presence, ADH4 enzymatic activity can increase due to substrate availability. | ||||||
AICAR | 2627-69-2 | sc-200659 sc-200659A sc-200659B | 50 mg 250 mg 1 g | $60.00 $270.00 $350.00 | 48 | |
AICAR, an AMPK activator, affects cellular metabolism. Its activation of AMPK can push cells towards catabolism, potentially enhancing the metabolic activity of ADH4. | ||||||
Zinc | 7440-66-6 | sc-213177 | 100 g | $47.00 | ||
Zinc is essential for ADH4's structural stability and function. In its presence, ADH4 can have enhanced stability and activity. | ||||||
Vitamin A | 68-26-8 | sc-280187 sc-280187A | 1 g 10 g | $377.00 $2602.00 | ||
Retinol can be metabolized by ADH4 into retinal. The conversion can enhance the enzyme's activity by serving as a substrate. | ||||||
2-Propanol | 67-63-0 | sc-391000C sc-391000 sc-391000B sc-391000A | 1 ml 25 ml 100 ml 500 ml | $32.00 $52.00 $62.00 $87.00 | 1 | |
Isopropanol is another alcohol that ADH4 can metabolize, and its presence can further boost the activity of ADH4. | ||||||