ADAMTS-16 Activators
ADAMTS-16 is a member of the ADAMTS (A Disintegrin and Metalloproteinase with Thrombospondin Motifs) family, which consists of extracellular enzymes critical for the cleavage and remodeling of the extracellular matrix (ECM). It contains a unique configuration of domains including a metalloproteinase domain, a disintegrin-like domain, and multiple thrombospondin motifs. This structural complexity allows it to interact with a range of substrates and other proteins in the ECM. ADAMTS-16 is involved in various biological processes including but not limited to tissue remodeling, cell migration, and possibly angiogenesis. The enzyme functions within complex signaling networks and its activity is regulated by multiple factors like zymogen activation, specific inhibitors, and availability of substrates. The expression of ADAMTS-16 can be influenced by various signaling pathways and transcriptional regulators, making it a part of an intricate web of cellular responses to environmental and intracellular cues.
ADAMTS-16 Activators comprises compounds that can either directly increase the enzymatic activity or indirectly stimulate its expression or functional availability. Direct activators are generally small molecules that interact with the enzyme to facilitate substrate binding, or enhance the enzyme's catalytic turnover. Indirect activators, on the other hand, can work through diverse mechanisms including inhibiting counteracting pathways, modifying epigenetic markers for elevated gene expression, or increasing the substrate availability for ADAMTS-16 in the ECM. Additionally, some molecules might activate upstream pathways that eventually culminate in an increase in ADAMTS-16 activity.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Sorafenib | 284461-73-0 | sc-220125 sc-220125A sc-220125B | 5 mg 50 mg 500 mg | $57.00 $100.00 $250.00 | 129 | |
PDGF Small Molecule Inhibitors could potentially influence ADAMTS activity by interfering with growth factor-mediated ECM remodeling. | ||||||
D,L-Sulforaphane | 4478-93-7 | sc-207495A sc-207495B sc-207495C sc-207495 sc-207495E sc-207495D | 5 mg 10 mg 25 mg 1 g 10 g 250 mg | $153.00 $292.00 $489.00 $1325.00 $8465.00 $933.00 | 22 | |
An Nrf2 activator that might influence ADAMTS enzymes, particularly under conditions of oxidative stress. | ||||||
Dimethyloxaloylglycine (DMOG) | 89464-63-1 | sc-200755 sc-200755A sc-200755B sc-200755C | 10 mg 50 mg 100 mg 500 mg | $84.00 $301.00 $374.00 $779.00 | 25 | |
A hydroxylase inhibitor that could affect the post-translational modifications of ADAMTS enzymes, thereby potentially influencing their stability or activity. | ||||||
N-Acetyl-L-cysteine | 616-91-1 | sc-202232 sc-202232A sc-202232C sc-202232B | 5 g 25 g 1 kg 100 g | $34.00 $74.00 $270.00 $114.00 | 34 | |
As a reactive oxygen species (ROS) scavenger, this molecule could potentially activate ADAMTS enzymes by reducing oxidative stress that may impair their activity. | ||||||
DAPT | 208255-80-5 | sc-201315 sc-201315A sc-201315B sc-201315C | 5 mg 25 mg 100 mg 1 g | $40.00 $120.00 $480.00 $2141.00 | 47 | |
A gamma-secretase inhibitor that interferes with Notch signaling, and could indirectly influence ADAMTS expression or activity. | ||||||
3-Aminopropionitrile | 151-18-8 | sc-266473 | 1 g | $104.00 | ||
Lysyl oxidase (LOX) inhibitors target the enzyme responsible for cross-linking collagen and elastin fibers in the extracellular matrix (ECM) and stabilize the ECM, affecting the substrate availability for ADAMTS. | ||||||
Esculetin | 305-01-1 | sc-200486 sc-200486A | 1 g 5 g | $44.00 $212.00 | 7 | |
A naturally occurring coumarin that has been shown to inhibit LOX activity. Lysyl oxidase (LOX) inhibitors target the enzyme responsible for cross-linking collagen and elastin fibers in the extracellular matrix (ECM) and stabilize the ECM, affecting the substrate availability for ADAMTS. | ||||||