ACSS2 Activators
ACSS2 activators, as identified in this context, are a collection of chemical compounds that indirectly influence the activity of ACSS2 through various metabolic pathways. These activators do not directly interact with ACSS2; instead, they create conditions that can increase the demand for acetyl-CoA, thereby potentially enhancing the activity of ACSS2 in its synthesis. The class includes compounds that influence NAD+ metabolism, AMP-activated protein kinase signaling, and overall lipid metabolism, which are all critical in determining the cellular demand for acetyl-CoA. For instance, compounds like Nicotinamide and Resveratrol, which affect sirtuin activity and metabolic pathways, can indirectly promote ACSS2 activity by influencing the regulatory mechanisms associated with lipid metabolism.
Additionally, compounds like Metformin and Berberine, known for their effects on AMPK signaling, can alter metabolic states in a way that increases the demand for acetyl-CoA, indirectly stimulating ACSS2 function. Other members of this class, including Curcumin, EGCG, and Sodium butyrate, exert their influence by modulating various signaling pathways related to metabolism, thus potentially enhancing ACSS2 activity. The impact of these compounds on ACSS2 is through an indirect modulation of metabolic demands and pathways within the cell, highlighting the interconnected nature of metabolic processes and the complexity of targeting specific enzymes like ACSS2.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Nicotinamide | 98-92-0 | sc-208096 sc-208096A sc-208096B sc-208096C | 100 g 250 g 1 kg 5 kg | $43.00 $65.00 $200.00 $815.00 | 6 | |
Nicotinamide, a form of vitamin B3, plays a role in NAD+ metabolism. Increased NAD+ levels can enhance the activity of sirtuins, which have been linked to the regulation of ACSS2, potentially promoting its activity in acetyl-CoA synthesis. | ||||||
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $60.00 $185.00 $365.00 | 64 | |
Resveratrol, a sirtuin activator, can indirectly influence ACSS2 by modulating sirtuin activity, which is involved in the regulation of lipid metabolism and may enhance the function of ACSS2 in acetyl-CoA synthesis. | ||||||
1,1-Dimethylbiguanide, Hydrochloride | 1115-70-4 | sc-202000F sc-202000A sc-202000B sc-202000C sc-202000D sc-202000E sc-202000 | 10 mg 5 g 10 g 50 g 100 g 250 g 1 g | $20.00 $42.00 $62.00 $153.00 $255.00 $500.00 $30.00 | 37 | |
Metformin, primarily used to regulate glucose metabolism, influences AMP-activated protein kinase (AMPK) signaling. AMPK activation can lead to metabolic changes that indirectly increase the demand for acetyl-CoA, potentially enhancing ACSS2 activity. | ||||||
Berberine | 2086-83-1 | sc-507337 | 250 mg | $90.00 | 1 | |
Berberine, an AMPK activator, can indirectly affect ACSS2 activity by modulating metabolic pathways, potentially increasing the need for acetyl-CoA and thus stimulating ACSS2's function. | ||||||
Sodium Butyrate | 156-54-7 | sc-202341 sc-202341B sc-202341A sc-202341C | 250 mg 5 g 25 g 500 g | $30.00 $46.00 $82.00 $218.00 | 19 | |
Sodium butyrate, a histone deacetylase inhibitor, affects gene expression. This can lead to indirect effects on metabolic pathways, potentially enhancing ACSS2 activity in acetyl-CoA synthesis. | ||||||
Curcumin | 458-37-7 | sc-200509 sc-200509A sc-200509B sc-200509C sc-200509D sc-200509F sc-200509E | 1 g 5 g 25 g 100 g 250 g 1 kg 2.5 kg | $36.00 $68.00 $107.00 $214.00 $234.00 $862.00 $1968.00 | 47 | |
Curcumin impacts several signaling pathways, including those related to metabolism. Its broad effects can indirectly influence ACSS2 activity by altering metabolic demands and pathways. | ||||||
(−)-Epigallocatechin Gallate | 989-51-5 | sc-200802 sc-200802A sc-200802B sc-200802C sc-200802D sc-200802E | 10 mg 50 mg 100 mg 500 mg 1 g 10 g | $42.00 $72.00 $124.00 $238.00 $520.00 $1234.00 | 11 | |
EGCG, found in green tea, has multiple effects on cellular signaling. Its influence on metabolic pathways can indirectly enhance ACSS2 activity by altering the cellular demand for acetyl-CoA. | ||||||
α-Lipoic Acid | 1077-28-7 | sc-202032 sc-202032A sc-202032B sc-202032C sc-202032D | 5 g 10 g 250 g 500 g 1 kg | $68.00 $120.00 $208.00 $373.00 $702.00 | 3 | |
Alpha-lipoic acid, an antioxidant, influences mitochondrial function and metabolism. This can indirectly affect ACSS2 by altering the cellular metabolic state and increasing the demand for acetyl-CoA. | ||||||
Quercetin | 117-39-5 | sc-206089 sc-206089A sc-206089E sc-206089C sc-206089D sc-206089B | 100 mg 500 mg 100 g 250 g 1 kg 25 g | $11.00 $17.00 $108.00 $245.00 $918.00 $49.00 | 33 | |
Quercetin, a flavonoid, influences various metabolic pathways. Its effect on these pathways can indirectly increase the demand for acetyl-CoA, potentially enhancing ACSS2 activity. | ||||||
Caffeine | 58-08-2 | sc-202514 sc-202514A sc-202514B sc-202514C sc-202514D | 5 g 100 g 250 g 1 kg 5 kg | $32.00 $66.00 $95.00 $188.00 $760.00 | 13 | |
Caffeine, a phosphodiesterase inhibitor, influences cellular energy metabolism. This effect can indirectly increase ACSS2 activity by altering the metabolic demand for acetyl-CoA. | ||||||