ACAT-1 Inhibitors
Items 1 to 10 of 15 total
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
N-[3-(4-hydroxyphenyl)-1-oxo-2-propenyl]-L-phenylalanine, methyl ester | 615264-52-3 | sc-221976 sc-221976A | 5 mg 10 mg | $45.00 $87.00 | 1 | |
N-[3-(4-hydroxyphenyl)-1-oxo-2-propenyl]-L-phenylalanine, methyl ester exhibits unique interactions with ACAT-1, characterized by its ability to stabilize enzyme-substrate complexes. This compound's structural features enable selective binding, influencing lipid droplet formation and cholesterol esterification processes. Its kinetic profile suggests a competitive inhibition mechanism, modulating lipid metabolism pathways. Additionally, the presence of the hydroxyphenyl group enhances molecular recognition, impacting overall enzymatic activity. | ||||||
3,4-dihydroxy Hydrocinnamic acid (L-Aspartic acid dibenzyl ester) amide | 615264-62-5 | sc-223562 sc-223562A sc-223562B sc-223562C | 5 mg 10 mg 50 mg 100 mg | $42.00 $106.00 $336.00 $588.00 | ||
3,4-Dihydroxy Hydrocinnamic acid (L-Aspartic acid dibenzyl ester) amide demonstrates intriguing interactions with ACAT-1, primarily through its dual hydroxyl groups that facilitate hydrogen bonding with the enzyme's active site. This compound's unique stereochemistry allows for enhanced substrate affinity, influencing the kinetics of cholesterol esterification. Its structural conformation promotes distinct molecular recognition patterns, potentially altering lipid homeostasis and metabolic regulation. | ||||||
Nicotinamide | 98-92-0 | sc-208096 sc-208096A sc-208096B sc-208096C | 100 g 250 g 1 kg 5 kg | $43.00 $65.00 $200.00 $815.00 | 6 | |
Nicotinamide inhibits SIRT1, leading to increased acetylation of ACAT-1 regulatory proteins and potentially reducing its activity. | ||||||
Terpendole C | 156967-65-6 | sc-391042 | 1 mg | $350.00 | ||
Terpendole C exhibits a unique affinity for ACAT-1, characterized by its ability to engage in specific hydrophobic interactions within the enzyme's active site. The compound's intricate molecular structure enhances its binding efficiency, leading to altered reaction kinetics in cholesterol metabolism. Additionally, its conformational flexibility allows for dynamic interactions with lipid substrates, potentially influencing the enzyme's regulatory mechanisms and overall lipid dynamics. | ||||||
A 922500 | 959122-11-3 | sc-203793 | 10 mg | $265.00 | 2 | |
A 922500 demonstrates a remarkable selectivity for ACAT-1, facilitated by its unique electrostatic interactions that stabilize the enzyme-substrate complex. This compound's rigid framework promotes a precise fit within the active site, enhancing its inhibitory potency. Furthermore, its ability to modulate the enzyme's conformational states may disrupt normal lipid processing pathways, thereby affecting the overall lipid homeostasis and influencing cellular lipid distribution. | ||||||
Simvastatin | 79902-63-9 | sc-200829 sc-200829A sc-200829B sc-200829C | 50 mg 250 mg 1 g 5 g | $30.00 $87.00 $132.00 $434.00 | 13 | |
Simvastatin inhibits HMG-CoA reductase, indirectly decreasing substrate availability for ACAT-1 and potentially reducing its activity. | ||||||
Avasimibe | 166518-60-1 | sc-364315 sc-364315A sc-364315B sc-364315C | 10 mg 50 mg 500 mg 1 g | $107.00 $413.00 $2040.00 $3060.00 | 1 | |
Avasimibe directly inhibits ACAT-1, preventing cholesterol esterification and decreasing cellular cholesterol storage. | ||||||
AICAR | 2627-69-2 | sc-200659 sc-200659A sc-200659B | 50 mg 250 mg 1 g | $60.00 $270.00 $350.00 | 48 | |
AICAR activates AMPK, indirectly inhibiting ACAT-1 by promoting ACC phosphorylation and reducing fatty acid synthesis. | ||||||
T0070907 | 313516-66-4 | sc-203287 | 5 mg | $138.00 | 1 | |
T0070907 inhibits PPARγ, potentially reducing ACAT-1 expression by interfering with its transcriptional regulation. | ||||||
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $62.00 $155.00 $320.00 | 233 | |
Rapamycin inhibits mTOR, indirectly affecting ACAT-1 by disrupting downstream signaling related to lipid metabolism. | ||||||