ACADL Inhibitors
ACADL inhibitors are a class of chemical compounds designed to target and inhibit the activity of the ACADL (acyl-CoA dehydrogenase, long-chain) enzyme, which plays a critical role in fatty acid β-oxidation, specifically in the metabolism of long-chain fatty acids. ACADL is responsible for catalyzing the initial dehydrogenation step of long-chain acyl-CoA molecules, which is an essential process in energy production through the oxidation of fatty acids in mitochondria. By inhibiting ACADL, these compounds disrupt the breakdown of long-chain fatty acids into smaller molecules that can be used in subsequent metabolic pathways. This inhibition can lead to changes in lipid metabolism and energy production, offering insights into the regulation of fatty acid oxidation and its impact on cellular functions.
Chemically, ACADL inhibitors can vary widely, with some designed as small molecules that target the enzyme's active site where the dehydrogenation reaction occurs. These inhibitors often bind directly to the flavin adenine dinucleotide (FAD)-binding domain, a critical cofactor for the enzymatic activity of ACADL. By preventing the binding of FAD or interfering with the interaction between FAD and the substrate, these inhibitors block the enzyme's catalytic function. Others may induce conformational changes that affect the overall structure of the enzyme, reducing its ability to interact with long-chain acyl-CoA substrates. Through these mechanisms, ACADL inhibitors serve as useful tools for studying fatty acid metabolism and the role of long-chain acyl-CoA dehydrogenase in mitochondrial function, as well as the broader processes related to lipid utilization and energy homeostasis within cells.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Trichostatin A | 58880-19-6 | sc-3511 sc-3511A sc-3511B sc-3511C sc-3511D | 1 mg 5 mg 10 mg 25 mg 50 mg | $152.00 $479.00 $632.00 $1223.00 $2132.00 | 33 | |
Trichostatin A may downregulate ACADL expression by specifically inhibiting histone deacetylase activity, leading to increased acetylation of histone proteins near the ACADL gene promoter, which can repress transcription. | ||||||
5-Azacytidine | 320-67-2 | sc-221003 | 500 mg | $280.00 | 4 | |
By incorporating into DNA, 5-Azacytidine could reduce ACADL expression by causing direct hypomethylation of its gene promoter, which typically suppresses gene transcription initiation. | ||||||
Valproic Acid | 99-66-1 | sc-213144 | 10 g | $87.00 | 9 | |
Valproic Acid might decrease ACADL expression by inhibiting histone deacetylase enzymes, thereby causing hyperacetylation of histones at the ACADL gene locus, leading to transcriptional repression. | ||||||
Sodium Butyrate | 156-54-7 | sc-202341 sc-202341B sc-202341A sc-202341C | 250 mg 5 g 25 g 500 g | $31.00 $47.00 $84.00 $222.00 | 19 | |
Sodium Butyrate could decrease ACADL transcription by inhibiting histone deacetylases, increasing histone acetylation in the promoter region of the ACADL gene and resulting in transcriptional silencing. | ||||||
Mithramycin A | 18378-89-7 | sc-200909 | 1 mg | $55.00 | 6 | |
Mithramycin A may bind to the GC-rich regions of the ACADL gene promoter, displacing transcription factors and thereby decreasing ACADL gene transcription. | ||||||
Retinoic Acid, all trans | 302-79-4 | sc-200898 sc-200898A sc-200898B sc-200898C | 500 mg 5 g 10 g 100 g | $66.00 $325.00 $587.00 $1018.00 | 28 | |
Retinoic acid might downregulate ACADL by binding to retinoic acid receptors that interact with retinoic acid response elements in the ACADL gene promoter, repressing gene transcription. | ||||||
Hydroxyurea | 127-07-1 | sc-29061 sc-29061A | 5 g 25 g | $78.00 $260.00 | 18 | |
Hydroxyurea could inhibit the expression of ACADL by disrupting the deoxyribonucleotide balance, resulting in inhibition of DNA replication and subsequent reduction in gene transcription. | ||||||
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $78.00 $153.00 $740.00 $1413.00 $2091.00 | 73 | |
Forskolin could decrease ACADL expression by elevating intracellular cAMP levels, which may lead to the activation of protein kinase A and alteration of transcription factor binding to the ACADL promoter. | ||||||
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $63.00 $158.00 $326.00 | 233 | |
Rapamycin may downregulate ACADL expression by specifically inhibiting mTOR signaling, which is crucial for protein synthesis, potentially leading to a general reduction in mRNA transcription including that of ACADL. | ||||||
Sorafenib | 284461-73-0 | sc-220125 sc-220125A sc-220125B | 5 mg 50 mg 500 mg | $57.00 $100.00 $250.00 | 129 | |
Sorafenib has the potential to inhibit ACADL expression by targeting multiple tyrosine kinases and downstream signaling pathways that are involved in the transcriptional regulation of the ACADL gene. | ||||||