ABCG4 Activators
ABCG4 activators are a class of chemical compounds that specifically interact with and modulate the activity of the ATP-binding cassette transporter G4 (ABCG4). ABC transporters are a large family of proteins that play a critical role in the transport of various molecules across cellular membranes using the energy found in ATP hydrolysis. The ABCG4 protein is a half-transporter, meaning it likely needs to dimerize with either another ABCG4 or a different compatible half-transporter to form a functional unit capable of transporting substrates. The exact physiological substrates of ABCG4 are not fully elucidated, but it is thought to be involved in the transport of certain lipids, potentially influencing lipid homeostasis and distribution within the body.
ABCG4 activators are designed to increase the transport activity of ABCG4 by enhancing its ability to bind and hydrolyze ATP and subsequently translocate its substrates. The mechanism by which these activators work can vary; some may directly bind to the transporter and induce a conformational change that increases its activity, while others may increase the expression of ABCG4, thus indirectly upregulating its transport capacity. The molecular design of ABCG4 activators requires a detailed understanding of the transporter's structure and the conformational changes it undergoes during the transport cycle. By binding to specific domains of the protein, these activators can facilitate the coupling of ATP hydrolysis to substrate movement.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Retinoic Acid, all trans | 302-79-4 | sc-200898 sc-200898A sc-200898B sc-200898C | 500 mg 5 g 10 g 100 g | $65.00 $319.00 $575.00 $998.00 | 28 | |
Retinoic acid can bind to nuclear retinoic acid receptors, which can in turn bind to specific elements in the ABCG4 gene promoter, potentially leading to an increase in its expression. | ||||||
Curcumin | 458-37-7 | sc-200509 sc-200509A sc-200509B sc-200509C sc-200509D sc-200509F sc-200509E | 1 g 5 g 25 g 100 g 250 g 1 kg 2.5 kg | $36.00 $68.00 $107.00 $214.00 $234.00 $862.00 $1968.00 | 47 | |
Curcumin, as a polyphenol from turmeric, has been implicated in the enhancement of various ABC transporter genes. It could potentially stimulate ABCG4 expression via specific interactions with cellular signaling pathways. | ||||||
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $60.00 $185.00 $365.00 | 64 | |
Resveratrol, through its antioxidant activity or activation of specific transcription factors, may upregulate the expression of ABCG4. | ||||||
D,L-Sulforaphane | 4478-93-7 | sc-207495A sc-207495B sc-207495C sc-207495 sc-207495E sc-207495D | 5 mg 10 mg 25 mg 1 g 10 g 250 mg | $150.00 $286.00 $479.00 $1299.00 $8299.00 $915.00 | 22 | |
DL-Sulforaphane may have the potential to stimulate ABCG4 expression via activation of the Nrf2 signaling pathway which is known to control the expression of many genes. | ||||||
(−)-Epigallocatechin Gallate | 989-51-5 | sc-200802 sc-200802A sc-200802B sc-200802C sc-200802D sc-200802E | 10 mg 50 mg 100 mg 500 mg 1 g 10 g | $42.00 $72.00 $124.00 $238.00 $520.00 $1234.00 | 11 | |
(-)-Epigallocatechin Gallate could potentially stimulate ABCG4 expression through its interaction with various cellular signaling pathways which control gene expression. | ||||||
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $76.00 $150.00 $725.00 $1385.00 $2050.00 | 73 | |
Forskolin increases intracellular levels of cAMP, which might trigger a cascade of events leading to the potential upregulation of ABCG4 expression through PKA-mediated transcription factor activation. | ||||||
Troglitazone | 97322-87-7 | sc-200904 sc-200904B sc-200904A | 5 mg 10 mg 25 mg | $108.00 $200.00 $426.00 | 9 | |
Troglitazone could induce ABCG4 expression by activating peroxisome proliferator-activated receptor gamma (PPARγ), which may bind to PPAR-responsive elements in the ABCG4 promoter region. | ||||||
Genistein | 446-72-0 | sc-3515 sc-3515A sc-3515B sc-3515C sc-3515D sc-3515E sc-3515F | 100 mg 500 mg 1 g 5 g 10 g 25 g 100 g | $26.00 $92.00 $120.00 $310.00 $500.00 $908.00 $1821.00 | 46 | |
Genistein has been shown to inhibit tyrosine kinases and alter transcription factor activity, which could potentially lead to an increase in ABCG4 expression. | ||||||
Quercetin | 117-39-5 | sc-206089 sc-206089A sc-206089E sc-206089C sc-206089D sc-206089B | 100 mg 500 mg 100 g 250 g 1 kg 25 g | $11.00 $17.00 $108.00 $245.00 $918.00 $49.00 | 33 | |
Quercetin, through its antioxidant activity or by altering the activity of specific transcription factors, may stimulate the expression of ABCG4. | ||||||
Dexamethasone | 50-02-2 | sc-29059 sc-29059B sc-29059A | 100 mg 1 g 5 g | $76.00 $82.00 $367.00 | 36 | |
Dexamethasone might boost ABCG4 expression through its interaction with the glucocorticoid receptor, leading to altered gene transcription. | ||||||