AATM Activators

AATM activators belong to a distinctive chemical class characterized by their unique ability to modulate specific cellular pathways and processes in various organisms. The term AATM stands for Allosteric Activator of Transcriptional Machinery, indicating their role in regulating gene expression at the transcriptional level. These compounds are known for their molecular interactions with transcriptional machinery components, particularly transcription factors and RNA polymerases. AATM activators act as allosteric effectors, binding to specific sites on these macromolecules and inducing conformational changes that enhance their activity.

Chemically, AATM activators can encompass a diverse range of organic molecules, including small organic compounds, peptides, or even larger macromolecules. Their commonality lies in their ability to interact with transcriptional machinery elements in a manner that leads to increased transcription of target genes. This may involve stabilizing transcription factor-DNA interactions, promoting RNA polymerase recruitment, or facilitating the assembly of transcriptional complexes.