KOR Inhibitors
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Naloxone hydrochloride | 357-08-4 | sc-203153 sc-203153A sc-203153B sc-203153C | 50 mg 100 mg 1 g 10 g | $87.00 $169.00 $342.00 $1864.00 | 2 | |
Naloxone hydrochloride exhibits a unique affinity for kappa-opioid receptors (KOR), where it acts as an antagonist, effectively blocking receptor activation. Its structural conformation allows for specific interactions with the receptor's binding site, influencing downstream signaling pathways. The compound's hydrophilic nature enhances its solubility in aqueous environments, promoting efficient transport across biological membranes. Additionally, its rapid kinetics contribute to a swift onset of action in receptor modulation studies. | ||||||
Nalmefene hydrochloride | 58895-64-0 | sc-361270 sc-361270A sc-361270B sc-361270C sc-361270D | 100 mg 500 mg 1 g 5 g 10 g | $159.00 $296.00 $377.00 $893.00 $1325.00 | ||
Nalmefene hydrochloride is characterized by its selective binding to kappa-opioid receptors (KOR), where it functions as a modulator. The compound's unique stereochemistry facilitates distinct interactions with receptor sites, altering conformational dynamics and influencing intracellular signaling cascades. Its amphipathic properties enhance membrane permeability, allowing for effective distribution in various environments. Furthermore, its reaction kinetics reveal a notable balance between affinity and dissociation, impacting its overall receptor engagement profile. | ||||||
nor-Binaltorphimine dihydrochloride | 105618-26-6 | sc-396970A sc-396970 | 1 mg 10 mg | $49.00 $190.00 | 4 | |
Nor-Binaltorphimine dihydrochloride exhibits a high affinity for kappa-opioid receptors (KOR), showcasing its ability to induce specific conformational changes upon binding. This compound's unique structural features promote selective interactions that can modulate receptor activity and downstream signaling pathways. Its hydrophilic and lipophilic characteristics contribute to its solubility and distribution, while its kinetic profile highlights a rapid onset of action, influencing receptor occupancy dynamics. | ||||||
DIPPA hydrochloride | 155512-52-0 | sc-221550 sc-221550A | 1 mg 5 mg | $20.00 $90.00 | ||
DIPPA hydrochloride is characterized by its selective binding to kappa-opioid receptors (KOR), where it engages in unique molecular interactions that stabilize receptor conformations. The compound's distinct functional groups facilitate specific hydrogen bonding and hydrophobic interactions, enhancing its affinity. Additionally, its dynamic reaction kinetics allow for efficient receptor activation, influencing downstream signaling cascades and contributing to its overall pharmacological profile. | ||||||
(S)-DIPPA hydrochloride | sc-311534 | 5 mg | $599.00 | |||
(S)-DIPPA hydrochloride exhibits a remarkable affinity for kappa-opioid receptors (KOR), driven by its stereochemistry that promotes optimal spatial orientation for receptor engagement. The compound's unique structural features enable it to form intricate electrostatic interactions and pi-stacking with aromatic residues, enhancing binding stability. Its rapid association and dissociation kinetics suggest a finely tuned mechanism of action, allowing for nuanced modulation of receptor activity and downstream effects. | ||||||
5′-Guanidinonaltrindole di(trifluoroacetate) | 219655-57-9 | sc-252280 | 5 mg | $406.00 | ||
5'-Guanidinonaltrindole di(trifluoroacetate) is a potent kappa-opioid receptor (KOR) ligand characterized by its guanidine moiety, which facilitates strong hydrogen bonding and ionic interactions with receptor sites. The trifluoroacetate groups enhance solubility and stability, promoting effective receptor engagement. Its unique conformational flexibility allows for dynamic interactions within the receptor's binding pocket, influencing signaling pathways and receptor conformational states. | ||||||