9330182L06Rik Activators
Chemical activators of endosome-lysosome associated apoptosis and autophagy regulator family member 2 can influence the cellular mechanisms that govern endosomal maturation, lysosomal function, and autophagy. Phosphatidylinositol 3-phosphate, for instance, enhances early endosomal maturation which is essential for the downstream fusion of endosomes with lysosomes. Eicosapentaenoic acid, on the other hand, alters the cellular lipid composition, impacting the formation and function of endosome-lysosome complexes. Sphingosine-1-phosphate modulates sphingolipid signaling pathways, affecting lysosomal membrane dynamics, while U18666A disrupts cholesterol trafficking, leading to the accumulation of cholesterol within endolysosomal compartments which in turn affects their function and fusion. Lysobisphosphatidic acid promotes the formation of intralumenal vesicles in endosomes that are necessary for proper trafficking, whereas leupeptin inhibits lysosomal proteases, leading to the accumulation of autophagic vacuoles and triggering compensatory autophagy mechanisms.
In addition to these lipid-related activators, several other compounds also play a role in the activation of endosome-lysosome associated apoptosis and autophagy regulator family member 2 through different mechanisms. Monensin alters the endosomal pH, which is vital for the endosomal sorting and maturation process, while bafilomycin A1 inhibits V-ATPase, impairing lysosomal acidification which promotes autophagic flux. Rapamycin, known for its action on mTOR signaling, induces autophagy, a process that relies on the endosome-lysosome system for the degradation of autophagosomes. Chloroquine, by raising the pH of endosomes and lysosomes, results in impaired degradation within these organelles. Lastly, 3-methyladenine and wortmannin both inhibit phosphatidylinositol 3-kinases, which are crucial for autophagosome formation and their subsequent fusion with lysosomes, thus affecting the autophagic-lysosomal degradation pathway. Each of these chemicals, through their distinct mechanisms, converges on the activation of endosome-lysosome associated apoptosis and autophagy regulator family member 2, highlighting the multifaceted nature of intracellular trafficking and degradation processes.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Eicosa-5Z,8Z,11Z,14Z,17Z-pentaenoic Acid (20:5, n-3) | 10417-94-4 | sc-200766 sc-200766A | 100 mg 1 g | $104.00 $431.00 | ||
Eicosapentaenoic acid activates endosome-lysosome associated apoptosis and autophagy regulator family member 2 by altering cellular lipid composition, which can influence the formation and function of endosome-lysosome complexes. | ||||||
D-erythro-Sphingosine-1-phosphate | 26993-30-6 | sc-201383 sc-201383D sc-201383A sc-201383B sc-201383C | 1 mg 2 mg 5 mg 10 mg 25 mg | $165.00 $322.00 $570.00 $907.00 $1727.00 | 7 | |
Sphingosine-1-phosphate activates endosome-lysosome associated apoptosis and autophagy regulator family member 2 by modulating sphingolipid signaling pathways that govern lysosomal membrane dynamics. | ||||||
U 18666A | 3039-71-2 | sc-203306 sc-203306A | 10 mg 50 mg | $143.00 $510.00 | 2 | |
U18666A activates endosome-lysosome associated apoptosis and autophagy regulator family member 2 by disrupting cholesterol trafficking and accumulation within endolysosomal compartments, thereby affecting endosome-lysosome function and fusion. | ||||||
Leupeptin hemisulfate | 103476-89-7 | sc-295358 sc-295358A sc-295358D sc-295358E sc-295358B sc-295358C | 5 mg 25 mg 50 mg 100 mg 500 mg 10 mg | $73.00 $148.00 $316.00 $499.00 $1427.00 $101.00 | 19 | |
Leupeptin activates endosome-lysosome associated apoptosis and autophagy regulator family member 2 by inhibiting lysosomal proteases which leads to the accumulation of autophagic vacuoles, thereby triggering compensatory autophagy mechanisms. | ||||||
Monensin A | 17090-79-8 | sc-362032 sc-362032A | 5 mg 25 mg | $155.00 $525.00 | ||
Monensin activates endosome-lysosome associated apoptosis and autophagy regulator family member 2 by altering endosomal pH, which is vital for the endosomal sorting and maturation process that precedes fusion with lysosomes. | ||||||
Bafilomycin A1 | 88899-55-2 | sc-201550 sc-201550A sc-201550B sc-201550C | 100 µg 1 mg 5 mg 10 mg | $98.00 $255.00 $765.00 $1457.00 | 280 | |
Bafilomycin A1 activates endosome-lysosome associated apoptosis and autophagy regulator family member 2 by inhibiting V-ATPase, which impairs lysosomal acidification and promotes compensatory processes enhancing autophagic flux. | ||||||
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $63.00 $158.00 $326.00 | 233 | |
Rapamycin activates endosome-lysosome associated apoptosis and autophagy regulator family member 2 by inhibiting mTOR signaling which induces autophagy, a process dependent on the endosome-lysosome system for the degradation of autophagosomes. | ||||||
Chloroquine | 54-05-7 | sc-507304 | 250 mg | $69.00 | 2 | |
Chloroquine activates endosome-lysosome associated apoptosis and autophagy regulator family member 2 by raising the pH of endosomes and lysosomes, resulting in impaired degradation and enhanced accumulation of autophagic vacuoles. | ||||||
Autophagy Inhibitor, 3-MA | 5142-23-4 | sc-205596 sc-205596A | 50 mg 500 mg | $65.00 $261.00 | 113 | |
3-Methyladenine activates endosome-lysosome associated apoptosis and autophagy regulator family member 2 by inhibiting phosphatidylinositol 3-kinases, which affects the formation of autophagosomes and their subsequent fusion with lysosomes. | ||||||
Wortmannin | 19545-26-7 | sc-3505 sc-3505A sc-3505B | 1 mg 5 mg 20 mg | $67.00 $223.00 $425.00 | 97 | |
Wortmannin activates endosome-lysosome associated apoptosis and autophagy regulator family member 2 by inhibiting PI3K, which is involved in early endosomal trafficking and autophagosome formation, integral to autophagic-lysosomal degradation. | ||||||