7530422B04Rik Inhibitors

The classification Dnmt3bos Inhibitors encompasses a broad spectrum of chemical compounds that share the capacity to influence the activity of DNA methyltransferase 3B (DNMT3B). DNMT3B is an enzyme that catalyzes the transfer of methyl groups to cytosine residues in DNA, a key epigenetic modification that can regulate gene expression. Inhibition of this enzyme can lead to changes in the methylation landscape of the genome, which can affect the expression and function of genes and associated non-coding RNAs, such as antisense transcripts like Dnmt3bos.

Compounds such as 5-azacytidine and decitabine are cytidine analogs that, once incorporated into DNA during replication, covalently bind to DNMTs, including DNMT3B. This binding results in the depletion of DNMT activity and a subsequent reduction in DNA methylation. Non-nucleoside compounds like RG108 and SGI-1027 inhibit DNMTs by binding to their active sites, thereby preventing them from methylating DNA. Other compounds, including natural products like EGCG, curcumin, quercetin, and oleuropein, have also been found to exhibit inhibitory effects on DNMTs, though the precise mechanisms may vary and are not fully understood.