6030422M02Rik Inhibitors

The classification of Mcmdc2 Inhibitors refers to compounds that indirectly affect the function of Mcmdc2, a protein involved in DNA replication. Since Mcmdc2 is part of the replication machinery, its activity is tightly linked to the overall process of DNA synthesis. The compounds listed target various stages of DNA replication and repair, which are processes where Mcmdc2 plays a role. Agents such as Aphidicolin and Hydroxyurea interfere with the availability of nucleotides or the activity of DNA polymerases, while nucleoside analogs like Gemcitabine, Fludarabine, Cladribine, and Cytarabine get incorporated into DNA or inhibit synthesis, leading to replication stress. This can impact the function of Mcmdc2, which is necessary for proper DNA replication.

Other compounds, such as 5-Fluorouracil and Thioguanine, introduce metabolic stress by inhibiting thymidylate synthase or incorporating into DNA as false nucleotides, respectively. This can cause DNA damage and replication forks stalling, where Mcmdc2's role is critical. Topoisomerase inhibitors like Etoposide and Camptothecin induce DNA breaks and interfere with the replication process, which can indirectly affect Mcmdc2 function. Mitoxantrone and Actinomycin D, by interfering with DNA replication and repair enzymes or by preventing RNA synthesis, respectively, can also impact the cellular processes that Mcmdc2 is involved in.