5830415F09Rik Inhibitors
Chemicals classified as TrmO Inhibitors do not directly target the enzyme tRNA methyltransferase O. Instead, they impact various cellular processes that are upstream or ancillary to the function of TrmO. These compounds typically interfere with tRNA synthesis, maturation, or the methylation machinery itself, leading to an indirect reduction in TrmO activity.
Actinomycin D, Rifampicin, and Mithramycin A are compounds that bind to DNA, thereby inhibiting RNA polymerase activity and subsequently decreasing the synthesis of tRNA, the substrate for TrmO. α-Amanitin selectively inhibits RNA polymerase II and III, which are responsible for synthesizing various classes of RNA, including tRNA. Neplanocin A and Mycophenolic acid disrupt the balance of nucleotide pools or the methylation cycle, consequently affecting the methyltransferase activity of TrmO. Antimetabolites like 5-fluorouracil, 5-azacytidine, Zebularine, and Decitabine are nucleoside analogs that can be incorporated into RNA molecules, leading to faulty tRNA molecules that may not be proper substrates for TrmO. Lastly, Hydralazine is known for its effects on DNA methylation but can also have consequences for RNA methylation patterns, thereby potentially affecting TrmO indirectly.
SEE ALSO...
Items 1 to 10 of 11 total
Display:
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Actinomycin D | 50-76-0 | sc-200906 sc-200906A sc-200906B sc-200906C sc-200906D | 5 mg 25 mg 100 mg 1 g 10 g | $74.00 $243.00 $731.00 $2572.00 $21848.00 | 53 | |
Binds to DNA and inhibits RNA polymerase, thereby preventing tRNA synthesis and indirectly affecting TrmO substrate availability. | ||||||
Rifampicin | 13292-46-1 | sc-200910 sc-200910A sc-200910B sc-200910C | 1 g 5 g 100 g 250 g | $97.00 $328.00 $676.00 $1467.00 | 6 | |
Inhibits bacterial RNA polymerase, thus can reduce tRNA levels and indirectly limit TrmO function in prokaryotes. | ||||||
Mithramycin A | 18378-89-7 | sc-200909 | 1 mg | $55.00 | 6 | |
Binds to DNA and prevents transcription by RNA polymerase, consequently reducing tRNA levels and TrmO activity. | ||||||
Cordycepin | 73-03-0 | sc-203902 | 10 mg | $101.00 | 5 | |
Inhibits RNA polyadenylation and can decrease the stability and synthesis of RNA, which can indirectly affect TrmO activity. | ||||||
α-Amanitin | 23109-05-9 | sc-202440 sc-202440A | 1 mg 5 mg | $269.00 $1050.00 | 26 | |
Inhibits eukaryotic RNA polymerase II and III, leading to decreased tRNA transcription and indirectly impacting TrmO activity. | ||||||
Mycophenolic acid | 24280-93-1 | sc-200110 sc-200110A | 100 mg 500 mg | $69.00 $266.00 | 8 | |
Inhibits inosine monophosphate dehydrogenase, causing a depletion of guanine nucleotides and potentially affecting tRNA synthesis and TrmO function. | ||||||
Fluorouracil | 51-21-8 | sc-29060 sc-29060A | 1 g 5 g | $37.00 $152.00 | 11 | |
Metabolized into nucleotide analogs that can be incorporated into RNA, potentially disrupting tRNA structure and affecting TrmO activity. | ||||||
5-Azacytidine | 320-67-2 | sc-221003 | 500 mg | $280.00 | 4 | |
Incorporated into RNA, can lead to disruption of RNA metabolism and indirectly affect TrmO activity. | ||||||
Zebularine | 3690-10-6 | sc-203315 sc-203315A sc-203315B | 10 mg 25 mg 100 mg | $129.00 $284.00 $1004.00 | 3 | |
A cytidine analog that can be incorporated into RNA, which may perturb RNA methylation processes, including those mediated by TrmO. | ||||||
5-Aza-2′-Deoxycytidine | 2353-33-5 | sc-202424 sc-202424A sc-202424B | 25 mg 100 mg 250 mg | $218.00 $322.00 $426.00 | 7 | |
A cytidine analog that, when incorporated into RNA, may disrupt RNA methylation and processing, indirectly affecting TrmO. | ||||||