5 alpha-Reductase 2 Inhibitors

Finasteride is a selective inhibitor of 5α-reductase 2, directly targeting the enzyme's active site. By binding to the catalytic site, Finasteride specifically inhibits the conversion of testosterone to dihydrotestosterone (DHT), a potent androgen.

Dutasteride is a dual inhibitor of 5α-reductase types 1 and 2, directly blocking the conversion of testosterone to DHT. By binding to the active sites of both isoforms, Dutasteride effectively reduces intracellular DHT levels.

α-Estradiol, also known as 17α-estradiol, is a compound that indirectly modulates 5α-reductase 2 activity. By acting as a competitive substrate for 5α-reductase, α-Estradiol competes with testosterone for binding to the enzyme's active site.

Ketoconazole is an antifungal agent that indirectly inhibits 5α-reductase 2 activity. By interfering with cytochrome P450 enzymes, including those involved in androgen synthesis, Ketoconazole disrupts the conversion of testosterone to DHT.

Abiraterone Acetate is a potent inhibitor of CYP17A1, a key enzyme involved in androgen synthesis. By blocking the activity of CYP17A1, Abiraterone Acetate indirectly modulates 5α-reductase 2 activity.

Azelaic Acid is a compound that indirectly influences 5α-reductase 2 activity. While the exact mechanism is not fully elucidated, Azelaic Acid is suggested to interfere with androgen metabolism and inhibit 5α-reductase activity.

Cimetidine is a histamine H2 receptor antagonist that indirectly modulates 5α-reductase 2 activity. By influencing the endocrine system, Cimetidine affects androgen metabolism, leading to an indirect impact on 5α-reductase 2.

Naringenin is a natural flavonoid that indirectly influences 5α-reductase 2 activity. While the exact mechanism is not fully elucidated, Naringenin is suggested to modulate androgen metabolism, impacting 5α-reductase activity indirectly.