4E-BP2 Inhibitors
4E-BP2 inhibitors belong to a distinctive class of chemical compounds that exert their influence on cellular signaling pathways. These inhibitors are primarily characterized by their ability to modulate the activity of the eukaryotic translation initiation factor 4E-binding protein 2 (4E-BP2). This protein is an integral component of the mTOR (mammalian target of rapamycin) pathway, which plays a crucial role in the regulation of protein synthesis and cellular growth. The function of 4E-BP2 centers around its interaction with the eukaryotic translation initiation factor 4E (eIF4E), a protein that participates in the initiation of cap-dependent translation.
By binding to eIF4E, 4E-BP2 hinders the assembly of the translation initiation complex and subsequently reduces the translation of specific mRNA molecules. In this context, 4E-BP2 inhibitors act as modulators of this interaction, potentially leading to alterations in protein synthesis rates and downstream cellular processes. The intricate interplay between 4E-BP2 inhibitors and the mTOR pathway highlights the significance of these compounds in potentially influencing cellular homeostasis and related functions.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $62.00 $155.00 $320.00 | 233 | |
Rapamycin is a well-known inhibitor of mTOR (mammalian target of rapamycin) pathway, which indirectly affects 4E-BPIt reduces phosphorylation of 4E-BP2, leading to reduced translation initiation. Used in immunosuppressive and anticancer therapies. | ||||||
Torin 1 | 1222998-36-8 | sc-396760 | 10 mg | $240.00 | 7 | |
An ATP-competitive mTOR inhibitor that effectively suppresses phosphorylation of 4E-BP2 and other downstream targets. It has been used in cancer research. | ||||||
PP242 | 1092351-67-1 | sc-301606A sc-301606 | 1 mg 5 mg | $56.00 $169.00 | 8 | |
Another mTOR inhibitor that blocks mTORC1 and mTORC2 activities, leading to dephosphorylation of 4E-BP2 and inhibiting translation initiation. | ||||||
AZD8055 | 1009298-09-2 | sc-364424 sc-364424A | 10 mg 50 mg | $160.00 $345.00 | 12 | |
An mTOR kinase inhibitor that can impact 4E-BP2 phosphorylation and protein synthesis. Investigated for potential anti-cancer effects. | ||||||
Ribociclib | 1211441-98-3 | sc-507367 | 10 mg | $450.00 | ||
This CDK4/6 inhibitor indirectly affects 4E-BP2 through the cell cycle regulation, altering its phosphorylation status and translation initiation. | ||||||
BEZ235 | 915019-65-7 | sc-364429 | 50 mg | $207.00 | 8 | |
A dual PI3K/mTOR inhibitor that indirectly influences 4E-BP2 phosphorylation and translation initiation. | ||||||
CGP 57380 | 522629-08-9 | sc-202993 | 5 mg | $172.00 | 6 | |
An inhibitor of p70 S6 kinase, an enzyme that phosphorylates 4E-BP2, thereby affecting translation initiation. | ||||||
Metformin | 657-24-9 | sc-507370 | 10 mg | $77.00 | 2 | |