4930485B16Rik Inhibitors

Cfap54 Inhibitors is a chemical class comprising agents that can indirectly modulate the function or expression of CFAP54 by influencing cellular pathways and processes related to ciliogenesis, the formation, and function of cilia and flagella. These chemicals are not specific inhibitors of CFAP54; instead, they target broader cellular functions that can, in turn, affect the activity of CFAP54 within ciliary structures.

Lithium chloride, cyclopamine, and alsterpaullone can impact the Wnt and Hedgehog signaling pathways, both of which are crucial in ciliary development and function. By altering these pathways, these chemicals can indirectly influence the role of CFAP54 in cilia and flagella. Rapamycin, through the inhibition of mTOR signaling, can affect cell growth and ciliary assembly, thereby impacting CFAP54 function. Chloral hydrate and ciliobrevin D can interfere with ciliary motility; forskolin can modify ciliary beat frequency, all potentially altering CFAP54's role in these processes. Zebularine and roscovitine can affect gene expression and cell cycle progression, respectively, which are critical for the proper formation and maintenance of cilia, and thus for the function of CFAP54. Demecolcine and brefeldin A can compromise the structural integrity and protein trafficking to cilia, respectively, which would impact CFAP54's localization and activity. U18666A, through its effect on cholesterol trafficking, can alter the ciliary membrane composition, potentially affecting CFAP54-associated functions.