2900097C17Rik Activators
Chemical activators of BSCL2 lipid droplet biogenesis associated, seipin, operate through various pathways to modulate its activity in lipid droplet formation and maintenance. Oleic Acid, for instance, directly interacts with the lipid monolayer of droplets, influencing their curvature and surface tension, which in turn can activate seipin's functional role in lipid droplet dynamics. Similarly, Arachidonic Acid, by integrating into lipid membranes, may engage signaling pathways that regulate lipid droplet formation, thereby facilitating the activation of seipin.
On the other hand, several chemicals function through peroxisome proliferator-activated receptor (PPAR) pathways to activate seipin. Pioglitazone and Rosiglitazone are PPAR-gamma agonists that enhance the transcription of genes involved in adipocyte differentiation and lipid metabolism, which can lead to seipin activation due to its role in lipid droplet formation. Clofibrate and Gemfibrozil, both PPAR-alpha agonists, and Bezafibrate, a pan-PPAR agonist, stimulate lipid metabolism pathways that necessitate increased lipid droplet formation, thus activating seipin. PPAR-delta agonists like L-165041 and GW501516 lead to heightened fatty acid oxidation and energy expenditure, which can prompt seipin's role in managing lipid droplet formation in metabolically active tissues. Additionally, GW7647, another PPAR-alpha agonist, triggers similar metabolic processes, thereby facilitating seipin's activation. Lastly, Telmisartan, while primarily an angiotensin II receptor blocker, also partially activates PPAR-gamma, which can lead to increased lipid storage and seipin activation in its capacity to manage lipid droplet dynamics.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Oleic Acid | 112-80-1 | sc-200797C sc-200797 sc-200797A sc-200797B | 1 g 10 g 100 g 250 g | $36.00 $102.00 $569.00 $1173.00 | 10 | |
Oleic Acid can activate BSCL2 lipid droplet biogenesis associated, seipin by integrating into the phospholipid monolayer of lipid droplets, thus potentially altering the lipid droplet curvature and surface tension, which can enhance seipin's role in lipid droplet formation and maintenance. | ||||||
Pioglitazone | 111025-46-8 | sc-202289 sc-202289A | 1 mg 5 mg | $54.00 $123.00 | 13 | |
Pioglitazone, a PPAR-gamma agonist, activates PPAR-gamma which can upregulate the transcription of genes involved in adipocyte differentiation and lipid metabolism. This activation cascade can lead to the functional activation of BSCL2 lipid droplet biogenesis associated, seipin in lipid processing. | ||||||
Clofibrate | 637-07-0 | sc-200721 | 1 g | $32.00 | ||
Clofibrate, as a PPAR-alpha agonist, can activate peroxisome proliferator-activated receptor alpha, which plays a role in lipid metabolism. This can lead to an increased demand for lipid droplet formation, consequently activating BSCL2 lipid droplet biogenesis associated, seipin's functional role. | ||||||
Bezafibrate | 41859-67-0 | sc-204650B sc-204650 sc-204650A sc-204650C | 500 mg 1 g 5 g 10 g | $30.00 $45.00 $120.00 $200.00 | 5 | |
Bezafibrate is a pan-PPAR agonist that can activate the PPAR family, including PPAR-alpha. The activation of this pathway can enhance fatty acid oxidation, which may necessitate increased lipid droplet formation and function, thereby activating BSCL2 lipid droplet biogenesis associated, seipin. | ||||||
Rosiglitazone | 122320-73-4 | sc-202795 sc-202795A sc-202795C sc-202795D sc-202795B | 25 mg 100 mg 500 mg 1 g 5 g | $118.00 $320.00 $622.00 $928.00 $1234.00 | 38 | |
Rosiglitazone is another PPAR-gamma agonist that can activate PPAR-gamma, leading to enhanced adipocyte differentiation and lipid storage. This activity can subsequently activate BSCL2 lipid droplet biogenesis associated, seipin as it is essential for lipid droplet formation and maintenance. | ||||||
Fenofibrate | 49562-28-9 | sc-204751 | 5 g | $40.00 | 9 | |
Fenofibrate activates PPAR-alpha, which can lead to an increased rate of lipid metabolism. This can result in the enhanced activity of BSCL2 lipid droplet biogenesis associated, seipin as it is pivotal in the formation and maintenance of lipid droplets, a key component of lipid metabolism. | ||||||
Gemfibrozil | 25812-30-0 | sc-204764 sc-204764A | 5 g 25 g | $65.00 $262.00 | 2 | |
Gemfibrozil, by acting as a PPAR-alpha agonist, can activate lipid metabolism pathways. The increased lipid turnover can activate BSCL2 lipid droplet biogenesis associated, seipin, since it plays a crucial role in lipid droplet formation, which is vital in the storage and metabolism of lipids. | ||||||
L-165041 | 79558-09-1 | sc-203094 | 5 mg | $153.00 | ||
L-165041 is a PPAR-delta agonist that can activate PPAR-delta, enhancing fatty acid oxidation and energy expenditure. This activation can prompt the functional activity of BSCL2 lipid droplet biogenesis associated, seipin in lipid droplet formation within metabolically active tissues. | ||||||
GW 7647 | 265129-71-3 | sc-203068A sc-203068 sc-203068B sc-203068C | 1 mg 5 mg 10 mg 25 mg | $48.00 $167.00 $262.00 $648.00 | 6 | |
GW7647 functions as a PPAR-alpha agonist, which can activate lipid metabolism and fatty acid oxidation. This process can lead to the activation of BSCL2 lipid droplet biogenesis associated, seipin as it supports the formation and maintenance of lipid droplets required in these metabolic processes. | ||||||
GW501516 | 317318-70-0 | sc-202642 sc-202642A | 1 mg 5 mg | $80.00 $175.00 | 28 | |
GW501516, a PPAR-delta agonist, can activate PPAR-delta pathways, resulting in increased fatty acid combustion. This activation can lead to the functional activation of BSCL2 lipid droplet biogenesis associated, seipin, due to its involvement in lipid droplet biology and energy homeostasis. | ||||||