The class of Tunar Inhibitors involves a variety of compounds that can modulate the synthesis, processing, or function of ncRNAs such as Tunar. These compounds exert their effects by targeting cellular mechanisms and pathways that indirectly affect the levels or activity of ncRNAs. For instance, Actinomycin D and α-Amanitin are well-characterized transcription inhibitors that can suppress RNA synthesis, including the transcription of ncRNAs. 5-Azacytidine and RG108 alter the epigenetic landscape, potentially affecting ncRNA expression through changes in DNA methylation patterns.
Furthermore, compounds like JQ1 and SAHA perturb the regulation of gene expression at the chromatin level, which can subsequently alter the expression of ncRNAs. Pladienolide B, by affecting spliceosome function, may change the maturation process of precursor RNAs, which includes some ncRNAs. Triptolide's broad transcription inhibition could similarly reduce ncRNA levels. Quercetin and bisphenol A are known to influence various signaling pathways and gene expression profiles, potentially altering ncRNA expression. Retinoic acid, with its role in modulating gene transcription, could also influence the expression profile of ncRNAs. Lastly, DRB's inhibition of RNA polymerase II provides another avenue for decreasing the transcription of ncRNAs.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Actinomycin D | 50-76-0 | sc-200906 sc-200906A sc-200906B sc-200906C sc-200906D | 5 mg 25 mg 100 mg 1 g 10 g | $74.00 $243.00 $731.00 $2572.00 $21848.00 | 53 | |
Interferes with DNA-dependent RNA synthesis, potentially decreasing the expression of ncRNAs. | ||||||
α-Amanitin | 23109-05-9 | sc-202440 sc-202440A | 1 mg 5 mg | $269.00 $1050.00 | 26 | |
Inhibits RNA polymerase II, potentially reducing the transcription of ncRNAs. | ||||||
5-Azacytidine | 320-67-2 | sc-221003 | 500 mg | $280.00 | 4 | |
A DNA methyltransferase inhibitor that can alter gene expression patterns, potentially affecting ncRNA expression. | ||||||
RG 108 | 48208-26-0 | sc-204235 sc-204235A | 10 mg 50 mg | $131.00 $515.00 | 2 | |
A DNA methyltransferase inhibitor that can change DNA methylation status, potentially influencing ncRNA expression. | ||||||
(±)-JQ1 | 1268524-69-1 | sc-472932 sc-472932A | 5 mg 25 mg | $231.00 $863.00 | 1 | |
Disrupts BET bromodomain proteins, affecting gene expression, which may alter ncRNA levels indirectly. | ||||||
Suberoylanilide Hydroxamic Acid | 149647-78-9 | sc-220139 sc-220139A | 100 mg 500 mg | $133.00 $275.00 | 37 | |
An HDAC inhibitor that can change chromatin structure and gene expression, potentially affecting ncRNA levels. | ||||||
Pladienolide B | 445493-23-2 | sc-391691 sc-391691B sc-391691A sc-391691C sc-391691D sc-391691E | 0.5 mg 10 mg 20 mg 50 mg 100 mg 5 mg | $299.00 $5699.00 $11099.00 $25500.00 $66300.00 $2875.00 | 63 | |
A spliceosome inhibitor that could affect the maturation of precursor RNAs, including ncRNAs. | ||||||
Triptolide | 38748-32-2 | sc-200122 sc-200122A | 1 mg 5 mg | $90.00 $204.00 | 13 | |
Inhibits transcription, which may reduce the expression of ncRNAs. | ||||||
Quercetin | 117-39-5 | sc-206089 sc-206089A sc-206089E sc-206089C sc-206089D sc-206089B | 100 mg 500 mg 100 g 250 g 1 kg 25 g | $11.00 $17.00 $110.00 $250.00 $936.00 $50.00 | 33 | |
A flavonoid that has been shown to modulate various signal transduction pathways, possibly influencing ncRNA expression. | ||||||
Bisphenol A | 80-05-7 | sc-391751 sc-391751A | 100 mg 10 g | $300.00 $490.00 | 5 | |
An endocrine disruptor that can alter gene expression and might impact the expression of ncRNAs. | ||||||