2700049P18Rik Activators
2700049P18Rik activators include a suite of small molecules that enhance the protein's activity through the modulation of various signaling pathways. Agents such as Forskolin and Epigallocatechin gallate (EGCG) function through the elevation of intracellular cAMP and inhibition of competitive kinases, respectively, both leading to an environment that favors the phosphorylation and subsequent activation of 2700049P18Rik. In a similar vein, PMA activates protein kinase C, which can phosphorylate components of signaling cascades intimately connected with 2700049P18Rik, potentially increasing the protein's activity. Ionomycin and A23187, calcium ionophores, elevate intracellular calcium levels, thus enabling calcium-dependent kinases or phosphatases to modify the activity of 2700049P18Rik. This is complemented by Thapsigargin, which disrupts calcium homeostasis, indirectly favoring 2700049P18Rik activation through calcium-dependent pathways.
Additionally, compounds like LY294002 and U0126 act by inhibiting PI3K and MEK1/2, respectively, which can lead to an upregulation of 2700049P18Rik activity by altering the equilibrium of signaling molecules. Sphingosine-1-phosphate, a lipid signaling molecule, and Staurosporine, a kinase inhibitor, may also enhance 2700049P18Rik activity by activating G protein-coupled receptors or selectively inhibiting kinases that regulate 2700049P18Rik activity. Piceatannol and Genistein, which inhibit Syk, JAK1, and tyrosine kinases, have the potential to shift cellular signaling in a way that relieves negative regulation on pathways involving 2700049P18Rik, promoting its functional activity. Collectively, these compounds, through their targeted effects on distinct signaling pathways, facilitate the enhancement of 2700049P18Rik's role within the cell without requiring transcriptional or translational modulation of the protein itself.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
(−)-Epigallocatechin Gallate | 989-51-5 | sc-200802 sc-200802A sc-200802B sc-200802C sc-200802D sc-200802E | 10 mg 50 mg 100 mg 500 mg 1 g 10 g | $42.00 $72.00 $124.00 $238.00 $520.00 $1234.00 | 11 | |
EGCG is a kinase inhibitor that can decrease competitive kinase activity. This reduction in kinase competition may allow for increased phosphorylation activity on specific sites of 2700049P18Rik, thus enhancing its functional activity within its specific signaling pathways. | ||||||
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $40.00 $129.00 $210.00 $490.00 $929.00 | 119 | |
PMA activates protein kinase C (PKC), which is involved in a multitude of signaling pathways. PKC-mediated phosphorylation can lead to the enhancement of 2700049P18Rik activity if PKC directly phosphorylates the protein or its immediate signaling partners. | ||||||
Ionomycin | 56092-82-1 | sc-3592 sc-3592A | 1 mg 5 mg | $76.00 $265.00 | 80 | |
Ionomycin is a calcium ionophore that increases intracellular calcium levels, leading to the activation of calcium-dependent kinases and phosphatases, which could enhance the phosphorylation state and activity of 2700049P18Rik within calcium signaling pathways. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $121.00 $392.00 | 148 | |
LY294002 is a PI3K inhibitor that can alter downstream signaling pathways, potentially enhancing 2700049P18Rik activity by shifting the balance of signaling molecules and reducing negative feedback loops that might otherwise suppress 2700049P18Rik functionality. | ||||||
D-erythro-Sphingosine-1-phosphate | 26993-30-6 | sc-201383 sc-201383D sc-201383A sc-201383B sc-201383C | 1 mg 2 mg 5 mg 10 mg 25 mg | $162.00 $316.00 $559.00 $889.00 $1693.00 | 7 | |
This lipid signaling molecule can activate G protein-coupled receptors, leading to downstream signaling events that enhance 2700049P18Rik activity, especially if 2700049P18Rik is involved in signaling pathways that are modulated by lipid-derived messengers. | ||||||
Thapsigargin | 67526-95-8 | sc-24017 sc-24017A | 1 mg 5 mg | $94.00 $349.00 | 114 | |
Thapsigargin disrupts calcium homeostasis by inhibiting the SERCA pump, leading to increased intracellular calcium and activation of calcium-dependent pathways that can enhance 2700049P18Rik activity. | ||||||
A23187 | 52665-69-7 | sc-3591 sc-3591B sc-3591A sc-3591C | 1 mg 5 mg 10 mg 25 mg | $54.00 $128.00 $199.00 $311.00 | 23 | |
A23187 is another calcium ionophore that increases intracellular calcium, activating calcium-dependent signaling pathways that could enhance the functional activity of 2700049P18Rik by increasing the phosphorylation state or changing the conformation of the protein. | ||||||
Staurosporine | 62996-74-1 | sc-3510 sc-3510A sc-3510B | 100 µg 1 mg 5 mg | $82.00 $150.00 $388.00 | 113 | |
Staurosporine is a broad-spectrum protein kinase inhibitor, but in a context-dependent manner, it may selectively enhance 2700049P18Rik activity by inhibiting kinases that negatively regulate 2700049P18Rik or its associated pathways. | ||||||
Piceatannol | 10083-24-6 | sc-200610 sc-200610A sc-200610B | 1 mg 5 mg 25 mg | $50.00 $70.00 $195.00 | 11 | |
Piceatannol inhibits Syk and JAK1 kinases, which might lead to the activation of alternative pathways or the relief of negative regulation on pathways in which 2700049P18Rik is involved, thereby enhancing its activity. | ||||||
Genistein | 446-72-0 | sc-3515 sc-3515A sc-3515B sc-3515C sc-3515D sc-3515E sc-3515F | 100 mg 500 mg 1 g 5 g 10 g 25 g 100 g | $26.00 $92.00 $120.00 $310.00 $500.00 $908.00 $1821.00 | 46 | |
Genistein is a tyrosine kinase inhibitor that can decrease competitive phosphorylation within the cell, potentially allowing for increased phosphorylation and activation of 2700049P18Rik if it is a substrate for tyrosine phosphorylation within its signaling pathways. | ||||||