2610002J02Rik Inhibitors

Chemical classes known as FAAP20 inhibitors encompass a range of compounds that, while not directly targeting FAAP20, can impinge on the FA pathway and related DNA repair processes in which FAAP20 is implicated. These compounds are diverse and affect various steps in DNA damage response and repair. For instance, agents like Mitomycin C and Cisplatin function by inducing DNA crosslinks, which can overwhelm the DNA repair machinery, thereby potentially diminishing the efficiency of FAAP20-related activities. Similarly, topoisomerase inhibitors such as Etoposide and Camptothecin result in DNA breaks that can saturate the FA pathway, impacting the role of FAAP20 within this complex network.

Other compounds in this chemical class include Hydroxyurea and Aphidicolin, which target DNA synthesis and replication enzymes, causing replication stress that can indirectly challenge the FA pathway and the functioning of FAAP20. B02, a RAD51 inhibitor, interferes with homologous recombination, a repair process where FAAP20 has a role. Trichostatin A, by modifying chromatin structure, could influence the efficiency of the FA pathway. DNA-PKcs and ATR inhibitors like Nu7441 and VE-821, respectively, hinder the repair of DNA double-strand breaks and replication stress responses, potentially affecting FAAP20's function in these pathways. Olaparib, a PARP inhibitor, on the other hand, traps PARP1 on DNA, causing replication fork stalling and subsequent double-strand breaks, thereby increasing the burden on the DNA repair machinery, including pathways involving FAAP20. Finally, Mirin inhibits the MRE11-RAD50-NBS1 complex, a key sensor of DNA double-strand breaks, which could indirectly pressure the FA pathway and the function of FAAP20.