2610002J02Rik Inhibitors
Chemical classes known as FAAP20 inhibitors encompass a range of compounds that, while not directly targeting FAAP20, can impinge on the FA pathway and related DNA repair processes in which FAAP20 is implicated. These compounds are diverse and affect various steps in DNA damage response and repair. For instance, agents like Mitomycin C and Cisplatin function by inducing DNA crosslinks, which can overwhelm the DNA repair machinery, thereby potentially diminishing the efficiency of FAAP20-related activities. Similarly, topoisomerase inhibitors such as Etoposide and Camptothecin result in DNA breaks that can saturate the FA pathway, impacting the role of FAAP20 within this complex network.
Other compounds in this chemical class include Hydroxyurea and Aphidicolin, which target DNA synthesis and replication enzymes, causing replication stress that can indirectly challenge the FA pathway and the functioning of FAAP20. B02, a RAD51 inhibitor, interferes with homologous recombination, a repair process where FAAP20 has a role. Trichostatin A, by modifying chromatin structure, could influence the efficiency of the FA pathway. DNA-PKcs and ATR inhibitors like Nu7441 and VE-821, respectively, hinder the repair of DNA double-strand breaks and replication stress responses, potentially affecting FAAP20's function in these pathways. Olaparib, a PARP inhibitor, on the other hand, traps PARP1 on DNA, causing replication fork stalling and subsequent double-strand breaks, thereby increasing the burden on the DNA repair machinery, including pathways involving FAAP20. Finally, Mirin inhibits the MRE11-RAD50-NBS1 complex, a key sensor of DNA double-strand breaks, which could indirectly pressure the FA pathway and the function of FAAP20.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Mitomycin C | 50-07-7 | sc-3514A sc-3514 sc-3514B | 2 mg 5 mg 10 mg | $65.00 $99.00 $140.00 | 85 | |
Interacts with DNA and creates crosslinks, preventing DNA replication and transcription, which can lead to increased pressure on the FA pathway, potentially compromising the function of proteins like FAAP20 involved in DNA repair. | ||||||
Cisplatin | 15663-27-1 | sc-200896 sc-200896A | 100 mg 500 mg | $76.00 $216.00 | 101 | |
Forms DNA adducts and intrastrand crosslinks, which can disrupt DNA replication and transcription, stressing the DNA repair pathways including the one involving FAAP20. | ||||||
Etoposide (VP-16) | 33419-42-0 | sc-3512B sc-3512 sc-3512A | 10 mg 100 mg 500 mg | $32.00 $170.00 $385.00 | 63 | |
Inhibits topoisomerase II, leading to DNA breaks. The resulting DNA damage can overload the DNA repair pathways and indirectly affect the function of FAAP20. | ||||||
Camptothecin | 7689-03-4 | sc-200871 sc-200871A sc-200871B | 50 mg 250 mg 100 mg | $57.00 $182.00 $92.00 | 21 | |
Inhibits topoisomerase I, causing DNA damage and increasing the demand on the DNA repair pathways, which can indirectly influence the function of FAAP20. | ||||||
Hydroxyurea | 127-07-1 | sc-29061 sc-29061A | 5 g 25 g | $76.00 $255.00 | 18 | |
Inhibits ribonucleotide reductase, leading to decreased deoxyribonucleotide pools and replication stress, which may indirectly affect the FA pathway and FAAP20’s role in it. | ||||||
Aphidicolin | 38966-21-1 | sc-201535 sc-201535A sc-201535B | 1 mg 5 mg 25 mg | $82.00 $300.00 $1082.00 | 30 | |
Inhibits DNA polymerase, leading to stalled replication forks, which can indirectly challenge the FA pathway and proteins like FAAP20. | ||||||
RAD51 Inhibitor B02 | 1290541-46-6 | sc-507533 | 10 mg | $95.00 | ||
Inhibitor of RAD51, a protein involved in homologous recombination, a key step in DNA repair processes where FAAP20 is implicated. Indirectly affecting FAAP20's role by inhibiting RAD51-mediated DNA repair. | ||||||
Trichostatin A | 58880-19-6 | sc-3511 sc-3511A sc-3511B sc-3511C sc-3511D | 1 mg 5 mg 10 mg 25 mg 50 mg | $149.00 $470.00 $620.00 $1199.00 $2090.00 | 33 | |
A histone deacetylase inhibitor that alters chromatin structure, potentially affecting the accessibility of DNA repair machinery and indirectly influencing the FA pathway and the role of FAAP20. | ||||||
NU 7441 | 503468-95-9 | sc-208107 | 5 mg | $350.00 | 10 | |
A DNA-PKcs inhibitor, which plays a crucial role in the non-homologous end joining pathway of DNA repair. By inhibiting DNA-PKcs, it may indirectly affect the FA pathway and the functioning of FAAP20. | ||||||
VE 821 | 1232410-49-9 | sc-475878 | 10 mg | $360.00 | ||
An ATR inhibitor; ATR is an essential kinase in the response to replication stress. Inhibiting ATR can lead to increased DNA damage and indirectly affect the FA pathway and FAAP20’s role in it. | ||||||