2310042D19Rik Inhibitors
The class of chemicals known as PGC-1α Inhibitors encompasses various compounds that can modulate the activity of PGC-1α indirectly. This modulation occurs through the influence on other proteins and signaling pathways that interact with PGC-1α. For example, AMPK activators such as AICAR and Metformin can phosphorylate PGC-1α, affecting its transcriptional coactivator functions. PPAR agonists like GW501516, Fenofibrate, Pioglitazone, and Rosiglitazone can alter PGC-1α expression levels and activity, thereby indirectly influencing the metabolic pathways in which PGC-1α is involved.
Additionally, SIRT1 activators, such as Resveratrol, and inhibitors like EX-527 can impact the acetylation status of PGC-1α, which is crucial for its activity and interaction with other transcription factors. This post-translational modification dictates PGC-1α's role in mitochondrial biogenesis and oxidative metabolism. The modulation of PGC-1α activity by these chemicals is significant because PGC-1α is a central regulatory hub for energy metabolism, controlling the expression of genes involved in mitochondrial function, gluconeogenesis, and fatty acid oxidation.
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Items 1 to 10 of 11 total
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
GW501516 | 317318-70-0 | sc-202642 sc-202642A | 1 mg 5 mg | $80.00 $175.00 | 28 | |
A PPARδ agonist that can increase PGC-1α expression in certain tissues, thereby altering its downstream effects on energy metabolism. | ||||||
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $60.00 $185.00 $365.00 | 64 | |
SIRT1 activator; SIRT1 deacetylates PGC-1α, which can enhance its activity. The increased deacetylase activity can modulate the transcriptional effects of PGC-1α. | ||||||
AICAR | 2627-69-2 | sc-200659 sc-200659A sc-200659B | 50 mg 250 mg 1 g | $60.00 $270.00 $350.00 | 48 | |
An AMPK activator can lead to the phosphorylation of PGC-1α, which in turn can affect its activity and stability, influencing mitochondrial biogenesis and energy metabolism. | ||||||
Metformin | 657-24-9 | sc-507370 | 10 mg | $77.00 | 2 | |
An AMPK activator that can lead to altered PGC-1α activity through AMPK-mediated pathways, affecting gluconeogenesis and other metabolic processes. | ||||||
ZLN005 | 49671-76-3 | sc-474381A sc-474381 sc-474381B sc-474381C | 5 mg 10 mg 25 mg 50 mg | $44.00 $112.00 $156.00 $257.00 | ||
A small molecule that can activate PGC-1α transcriptional activity, potentially affecting the expression of genes involved in mitochondrial function and oxidative metabolism. | ||||||
EX 527 | 49843-98-3 | sc-203044 | 5 mg | $85.00 | 32 | |
An inhibitor of SIRT1, which can reduce the deacetylation of PGC-1α, thereby influencing its activity. | ||||||
Hesperidin | 520-26-3 | sc-205711 sc-205711A | 25 g 100 g | $80.00 $200.00 | 5 | |
Influences PGC-1α through its effects on AMPK and SIRT1, which can modulate mitochondrial function and biogenesis. | ||||||
Berberine | 2086-83-1 | sc-507337 | 250 mg | $90.00 | 1 | |
An AMPK activator that can influence PGC-1α activity and thereby affect mitochondrial biogenesis and function. | ||||||
Fenofibrate | 49562-28-9 | sc-204751 | 5 g | $40.00 | 9 | |
A PPARα agonist that can induce PGC-1α expression and modulate its activity, affecting lipid metabolism and mitochondrial function. | ||||||
Pioglitazone | 111025-46-8 | sc-202289 sc-202289A | 1 mg 5 mg | $54.00 $123.00 | 13 | |
A PPARγ agonist that can upregulate PGC-1α expression, potentially influencing glucose metabolism and insulin sensitivity. | ||||||