1700113H08Rik Inhibitors
1700113H08Rik inhibitors represent a specialized class of chemical compounds aimed at modulating the activity of the 1700113H08Rik protein, which is a gene product identified in murine models and associated with various cellular processes. The precise function of the 1700113H08Rik protein remains under investigation, but it is thought to be involved in regulating aspects of gene expression, protein interactions, or cellular signaling pathways. Inhibitors targeting 1700113H08Rik are designed to bind specifically to this protein, disrupting its normal function and allowing researchers to study its role in cellular mechanisms. These inhibitors can interfere with protein-protein interactions, enzyme activity, or other molecular functions associated with the 1700113H08Rik protein, providing a tool for exploring its biological significance.
The development of 1700113H08Rik inhibitors involves a combination of techniques, including bioinformatics, molecular modeling, and biochemical assays. Initial efforts focus on characterizing the structure of the 1700113H08Rik protein, using methods such as X-ray crystallography or nuclear magnetic resonance (NMR) spectroscopy to determine its three-dimensional configuration. This structural information is critical for identifying potential binding sites where inhibitors can interact with the protein. Once these sites are identified, computational methods are employed to design or screen chemical compounds that fit into these binding pockets, effectively blocking or altering the protein's activity. These candidate inhibitors are then synthesized and tested in vitro to assess their specificity, binding affinity, and impact on the function of 1700113H08Rik. Through iterative cycles of design, synthesis, and testing, researchers can optimize these inhibitors, refining their chemical structures to enhance their effectiveness. The study of 1700113H08Rik inhibitors not only provides insights into the specific functions of this protein but also contributes to a broader understanding of the molecular pathways it may influence within cellular contexts.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Wortmannin | 19545-26-7 | sc-3505 sc-3505A sc-3505B | 1 mg 5 mg 20 mg | $66.00 $219.00 $417.00 | 97 | |
Wortmannin is a potent inhibitor of phosphoinositide 3-kinases (PI3K), which are involved in various signaling pathways, including those regulating cell growth and survival. By inhibiting PI3K, Wortmannin could lead to a reduction in Akt signaling, a pathway that 1700113H08Rik might influence, resulting in the functional inhibition of this protein's role in cell proliferation and survival mechanisms. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $121.00 $392.00 | 148 | |
LY294002 is another PI3K inhibitor, similar to Wortmannin. It reduces Akt phosphorylation, diminishing the downstream signaling that can involve 1700113H08Rik, thereby functionally inhibiting any of its roles that are contingent on PI3K/Akt pathway activity. | ||||||
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $62.00 $155.00 $320.00 | 233 | |
Rapamycin selectively inhibits mTOR (mammalian target of rapamycin), which is downstream of PI3K/Akt signaling. Since mTOR is involved in protein synthesis and cell growth, inhibiting this kinase could indirectly hinder any functions of 1700113H08Rik that are dependent on mTOR's activity. | ||||||
SB 203580 | 152121-47-6 | sc-3533 sc-3533A | 1 mg 5 mg | $88.00 $342.00 | 284 | |
SB203580 is a selective inhibitor of p38 MAPK. The p38 MAP kinase pathway is implicated in inflammatory responses and stress, and its inhibition can alter cellular responses that 1700113H08Rik might be implicated in, particularly if 1700113H08Rik functions are stress-responsive. | ||||||
SP600125 | 129-56-6 | sc-200635 sc-200635A | 10 mg 50 mg | $40.00 $150.00 | 257 | |
SP600125 is an inhibitor of c-Jun N-terminal kinase (JNK), which is involved in regulating apoptosis and cell proliferation. Inhibiting JNK could lead to functional inhibition of 1700113H08Rik if it has roles that are regulated by the JNK signaling pathway. | ||||||
PD 98059 | 167869-21-8 | sc-3532 sc-3532A | 1 mg 5 mg | $39.00 $90.00 | 212 | |
PD98059 is a MEK inhibitor, which prevents the activation of the ERK/MAPK pathway. Since this pathway is involved in cell cycle and growth, inhibition by PD98059 could suppress any cell proliferation functions mediated by 1700113H08Rik through the ERK/MAPK pathway. | ||||||
U-0126 | 109511-58-2 | sc-222395 sc-222395A | 1 mg 5 mg | $63.00 $241.00 | 136 | |
U0126 also inhibits MEK, blocking the MEK/ERK pathway and potentially affecting cell cycle regulation. If 1700113H08Rik is involved in cell cycle regulation through this pathway, U0126 would functionally inhibit these activities. | ||||||
PP 2 | 172889-27-9 | sc-202769 sc-202769A | 1 mg 5 mg | $92.00 $223.00 | 30 | |
PP2 is a selective inhibitor of Src family kinases. Src kinases are implicated in various cellular processes, including proliferation and differentiation. Inhibition by PP2 might reduce 1700113H08Rik's functional involvement if it is associated with Src-mediated signaling. | ||||||
SB 431542 | 301836-41-9 | sc-204265 sc-204265A sc-204265B | 1 mg 10 mg 25 mg | $80.00 $212.00 $408.00 | 48 | |
SB431542 selectively inhibits the TGF-beta receptor type I (ALK5), and if 1700113H08Rik is involved in signaling pathways downstream of TGF-beta, this chemical would functionally inhibit those roles by blocking TGF-beta-mediated signaling. | ||||||
Doramapimod | 285983-48-4 | sc-300502 sc-300502A sc-300502B | 25 mg 50 mg 100 mg | $149.00 $281.00 $459.00 | 2 | |
BIRB 796 is a potent inhibitor of p38 MAPK. If 1700113H08Rik is involved in pathways regulated by p38 MAPK, such as stress responses or cytokine production, its functional role would be inhibited by BIRB 796's action on this kinase. | ||||||