1700016K19Rik Inhibitors
Chemical inhibitors of Protein LIAT1 target various signaling pathways and molecular mechanisms to impede the protein's function. Staurosporine, a well-known kinase inhibitor, disrupts the activity of Protein LIAT1 by binding to ATP-binding sites of kinases that are crucial for the protein's phosphorylation events. Similarly, Bisindolylmaleimide I focuses on inhibiting protein kinase C (PKC) isoforms, which are associated with the phosphorylation of Protein LIAT1 or its substrates. LY294002 and Wortmannin are other kinase inhibitors; LY294002 specifically interferes with the PI3K/AKT pathway, pivotal for the regulation of Protein LIAT1, while Wortmannin forms a covalent bond with phosphoinositide 3-kinases (PI3K), thus disrupting PI3K-dependent activation pathways.
On another front, Rapamycin forms a complex with FKBP12 that inhibits mTOR, a kinase integral to the signaling pathway that Protein LIAT1 relies on for its action. In the same vein, U0126 and PD98059 target the MEK1/2 and ERK pathways respectively, which are upstream regulators essential for Protein LIAT1's activation. SB203580 and SP600125 take alternative routes; SB203580 selectively hampers p38 MAP kinase, and SP600125 inhibits JNK, both kinases participating in distinct signaling cascades that govern Protein LIAT1's functionality. Dasatinib and PP2 share a similar mechanism of action, where they both inhibit Src family tyrosine kinases, critical for the phosphorylation events in signaling pathways on which Protein LIAT1's activity depends. Finally, ZM-447439 impedes Protein LIAT1 by targeting Aurora kinase activity, which is associated with cell cycle regulation and consequently, Protein LIAT1's function.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Staurosporine | 62996-74-1 | sc-3510 sc-3510A sc-3510B | 100 µg 1 mg 5 mg | $82.00 $150.00 $388.00 | 113 | |
Staurosporine inhibits Protein LIAT1 by antagonizing the ATP-binding sites of kinases that are critical for Protein LIAT1 function, thus preventing phosphorylation events necessary for Protein LIAT1's activity. | ||||||
Bisindolylmaleimide I (GF 109203X) | 133052-90-1 | sc-24003A sc-24003 | 1 mg 5 mg | $103.00 $237.00 | 36 | |
Bisindolylmaleimide I inhibits Protein LIAT1 by selectively blocking protein kinase C (PKC) isoforms, which are required for the phosphorylation of Protein LIAT1 or its substrates, thereby inhibiting Protein LIAT1's functional activity. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $121.00 $392.00 | 148 | |
LY294002 inhibits Protein LIAT1 by targeting the PI3K/AKT pathway, which is essential for the regulation of Protein LIAT1, leading to the inhibition of downstream signaling required for Protein LIAT1's activity. | ||||||
Wortmannin | 19545-26-7 | sc-3505 sc-3505A sc-3505B | 1 mg 5 mg 20 mg | $66.00 $219.00 $417.00 | 97 | |
Wortmannin serves as an inhibitor of Protein LIAT1 by covalently binding to and inhibiting phosphoinositide 3-kinases (PI3K), which are involved in the activation of pathways required for Protein LIAT1 function, thus inhibiting its activity. | ||||||
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $62.00 $155.00 $320.00 | 233 | |
Rapamycin inhibits Protein LIAT1 by binding to FKBP12 and the resulting complex inhibits mTOR, a kinase that is part of the signaling pathway necessary for Protein LIAT1's activity, thus leading to the inhibition of Protein LIAT1. | ||||||
U-0126 | 109511-58-2 | sc-222395 sc-222395A | 1 mg 5 mg | $63.00 $241.00 | 136 | |
U0126 inhibits Protein LIAT1 by selectively inhibiting MEK1/2, which are upstream regulators of the ERK pathway, a pathway upon which Protein LIAT1 relies for its activation and function, therefore inhibiting Protein LIAT1's activity. | ||||||
PD 98059 | 167869-21-8 | sc-3532 sc-3532A | 1 mg 5 mg | $39.00 $90.00 | 212 | |
PD98059 inhibits Protein LIAT1 by blocking MEK activation, which is necessary for the phosphorylation and activation of ERK pathway components that are required for Protein LIAT1 function, thereby leading to the inhibition of Protein LIAT1. | ||||||
SB 203580 | 152121-47-6 | sc-3533 sc-3533A | 1 mg 5 mg | $88.00 $342.00 | 284 | |
SB203580 inhibits Protein LIAT1 by selectively inhibiting p38 MAP kinase, which is involved in the signaling cascade that regulates Protein LIAT1's activity, thus leading to the inhibition of Protein LIAT1. | ||||||
SP600125 | 129-56-6 | sc-200635 sc-200635A | 10 mg 50 mg | $40.00 $150.00 | 257 | |
SP600125 inhibits Protein LIAT1 by inhibiting JNK, which is involved in stress signaling pathways that regulate Protein LIAT1's function, thus inhibiting Protein LIAT1's activity. | ||||||
Dasatinib | 302962-49-8 | sc-358114 sc-358114A | 25 mg 1 g | $47.00 $145.00 | 51 | |
Dasatinib inhibits Protein LIAT1 by targeting Src family tyrosine kinases, which are involved in the phosphorylation and activation of signaling pathways that regulate Protein LIAT1's function, thereby leading to the inhibition of Protein LIAT1. | ||||||