1600002K03Rik Inhibitors
Chemical inhibitors of protein kinase activity, such as the one exhibited by 1600002K03Rik, can serve as tools to understand the functional role of the protein in cellular processes. Staurosporine, a potent non-selective inhibitor, can block the ATP binding sites essential for the kinase activity of 1600002K03Rik. This action prevents phosphorylation events that are crucial for the protein's function. Similarly, Bisindolylmaleimide I targets protein kinase C, and by doing so, it can inhibit any PKC-dependent activation of 1600002K03Rik. In the same vein, LY294002 and Wortmannin, both PI3K inhibitors, can suppress the PI3K/AKT pathway, which, if 1600002K03Rik is a part, would result in reduced AKT activation and consequently diminished protein function.
Further, specific inhibitors that target particular signaling cascades can elucidate the involvement of 1600002K03Rik in these pathways. For instance, SP600125, which selectively inhibits c-Jun N-terminal kinase, can prevent JNK-mediated phosphorylation of 1600002K03Rik. PD98059 and U0126, both MEK inhibitors, reduce ERK activation and, if 1600002K03Rik operates downstream of this pathway, would thus inhibit its activity. Conversely, SB203580, a p38 MAPK inhibitor, and PP2, which inhibits Src family tyrosine kinases, can block the activation of 1600002K03Rik if it is regulated by p38 or Src kinase signaling, respectively. MK-2206, an AKT inhibitor, can also suppress the protein's function if it is AKT-dependent. Lastly, Dasatinib, known for its broad-spectrum inhibition of tyrosine kinases, including Src family kinases, can arrest the activation of 1600002K03Rik if it is associated with these kinases. Each of these inhibitors, by targeting different nodes of the signaling network, can contribute to a comprehensive understanding of the functional mechanisms of 1600002K03Rik within the cell.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Staurosporine | 62996-74-1 | sc-3510 sc-3510A sc-3510B | 100 µg 1 mg 5 mg | $82.00 $150.00 $388.00 | 113 | |
Staurosporine is a potent inhibitor of protein kinases. Considering that 1600002K03Rik is a kinase, staurosporine can inhibit its kinase activity by competing with ATP binding sites, thus preventing phosphorylation events necessary for 1600002K03Rik's function. | ||||||
Bisindolylmaleimide I (GF 109203X) | 133052-90-1 | sc-24003A sc-24003 | 1 mg 5 mg | $103.00 $237.00 | 36 | |
This inhibitor specifically targets protein kinase C (PKC), and if 1600002K03Rik's function is regulated by PKC-mediated phosphorylation, Bisindolylmaleimide I would inhibit 1600002K03Rik by preventing its PKC-dependent activation. | ||||||
SP600125 | 129-56-6 | sc-200635 sc-200635A | 10 mg 50 mg | $65.00 $267.00 | 257 | |
As a selective inhibitor of c-Jun N-terminal kinase (JNK), SP600125 inhibits JNK signaling. If 1600002K03Rik operates downstream of JNK or is activated by JNK-mediated phosphorylation, SP600125 would inhibit the functional activity of 1600002K03Rik by preventing this post-translational modification. | ||||||
PD 98059 | 167869-21-8 | sc-3532 sc-3532A | 1 mg 5 mg | $39.00 $90.00 | 212 | |
PD98059 selectively inhibits MEK, which is upstream of ERK in the MAPK pathway. If 1600002K03Rik's activity is dependent on ERK-mediated signaling, PD98059's inhibition of MEK would lead to decreased ERK activation and subsequent inhibition of 1600002K03Rik functional activity. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $121.00 $392.00 | 148 | |
LY294002 is a PI3K inhibitor. If 1600002K03Rik is part of the PI3K/AKT pathway or is regulated by PI3K signaling, the inhibition of PI3K by LY294002 would result in decreased AKT activation and subsequently inhibit the functional activity of 1600002K03Rik. | ||||||
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $62.00 $155.00 $320.00 | 233 | |
Rapamycin inhibits mTOR, which is a central protein in cell growth and metabolism regulation. If 1600002K03Rik functions downstream of the mTOR pathway or requires mTOR activity for its function, rapamycin would inhibit 1600002K03Rik by inhibiting mTOR activity. | ||||||
PP 2 | 172889-27-9 | sc-202769 sc-202769A | 1 mg 5 mg | $92.00 $223.00 | 30 | |
PP2 is a Src family tyrosine kinase inhibitor. If 1600002K03Rik is activated by Src kinase signaling, PP2 would inhibit the activation of Src kinases, thereby inhibiting the functional activity of 1600002K03Rik. | ||||||
U-0126 | 109511-58-2 | sc-222395 sc-222395A | 1 mg 5 mg | $63.00 $241.00 | 136 | |
U0126 is another MEK inhibitor, which would prevent the activation of ERK. If 1600002K03Rik requires ERK activation for its function, U0126 would inhibit 1600002K03Rik by inhibiting MEK and thus ERK signaling. | ||||||
SB 203580 | 152121-47-6 | sc-3533 sc-3533A | 1 mg 5 mg | $88.00 $342.00 | 284 | |
SB203580 is an inhibitor of p38 MAPK. If 1600002K03Rik is regulated by p38 MAPK signaling, the inhibition of p38 by SB203580 would prevent the phosphorylation and activation of 1600002K03Rik, therefore inhibiting its function. | ||||||
Wortmannin | 19545-26-7 | sc-3505 sc-3505A sc-3505B | 1 mg 5 mg 20 mg | $66.00 $219.00 $417.00 | 97 | |
Wortmannin is another PI3K inhibitor. Similar to LY294002, if 1600002K03Rik is involved in PI3K/AKT signaling, wortmannin's inhibition of PI3K would decrease AKT activation and thereby inhibit the functional activity of 1600002K03Rik. | ||||||