Molecular structure of Y-27632 dihydrochloride, CAS Number: 129830-38-2
Y-27632 dihydrochloride (CAS 129830-38-2)
See product citations (48)
Alternate Names:
Y-27632 dihydrochloride is also known as ROCK Inhibitor
Application:
Y-27632 dihydrochloride is a cell permeable inhibitor of ROCK-1 and ROCK-2 which plays an important role in Rho-mediated cell adhesion and smooth muscle contraction.
CAS Number:
129830-38-2
Purity:
≥98%
Molecular Weight:
320.26
Molecular Formula:
C14H21N3O•2HCl
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Y-27632 dihydrochloride is a selective Rho-kinase inhibitor. Y-27632 dihydrochloride suppresses cholinergic nerve-mediated contractions. In addition, studies show that Y-27632 dihydrochloride increases the release of neurotransmitters from cholinergic nerves. Studies conducted on smooth muscle preparations suggest that Y-27632 dihydrochloride suppresses nerve-mediated contractile responses stimulated by acetylcholine and noradrenaline. Furthermore, studies on lung tissue damage in rats suggest that Y-27632 dihydrochloride can restore the damage caused by oleic acid by inhibition of ROCK-1 and ROCK-2. Y-27632 dihydrochloride also inhibits protein kinase C related kinase, PRK2.
Y-27632 dihydrochloride (CAS 129830-38-2) References
- Specificity and mechanism of action of some commonly used protein kinase inhibitors. | Davies, SP., et al. 2000. Biochem J. 351: 95-105. PMID: 10998351
- Use and properties of ROCK-specific inhibitor Y-27632. | Narumiya, S., et al. 2000. Methods Enzymol. 325: 273-84. PMID: 11036610
- Rho-kinase (ROCK-1 and ROCK-2) upregulation in oleic acid-induced lung injury and its restoration by Y-27632. | Köksel, O., et al. 2005. Eur J Pharmacol. 510: 135-42. PMID: 15740734
- A Rho-kinase inhibitor, Y-27632, reduces cholinergic contraction but not neurotransmitter release. | Fernandes, L., et al. 2006. Eur J Pharmacol. 550: 155-61. PMID: 17010334
- Increased liver uptake and reduced hepatic stellate cell activation with a cell-specific conjugate of the Rho-kinase inhibitor Y27632. | van Beuge, MM., et al. 2011. Pharm Res. 28: 2045-54. PMID: 21442374
- Similar hydrodynamic and morphological changes in the aqueous humor outflow pathway after washout and Y27632 treatment in monkey eyes. | Lu, Z., et al. 2011. Exp Eye Res. 93: 397-404. PMID: 21669200
- Y27632 attenuates the aristolochic acid-promoted invasion and migration of human urothelial cancer TSGH cells in vitro and inhibits the growth of xenografts in vivo. | Huang, HP., et al. 2012. Nephrol Dial Transplant. 27: 565-75. PMID: 21799205
- ROCK inhibition with Y27632 promotes the proliferation and cell cycle progression of cultured astrocyte from spinal cord. | Yu, Z., et al. 2012. Neurochem Int. 61: 1114-20. PMID: 22929997
- Effects of Y27632 on keratinocyte procurement and wound healing. | Gandham, VD., et al. 2013. Clin Exp Dermatol. 38: 782-6. PMID: 23675999
- Effect of oxidative stress on Rho kinase II and smooth muscle contraction in rat stomach. | Al-Shboul, O. and Mustafa, A. 2015. Can J Physiol Pharmacol. 93: 405-11. PMID: 25752964
- Using Human Induced Pluripotent Stem Cell-derived Intestinal Organoids to Study and Modify Epithelial Cell Protection Against Salmonella and Other Pathogens. | Lees, EA., et al. 2019. J Vis Exp.. PMID: 31132035
- Expression of Acyl-CoA wax-alcohol acyltransferase 2 (AWAT2) by human and rabbit meibomian glands and meibocytes. | Rho, CR., et al. 2022. Ocul Surf. 23: 60-70. PMID: 34838721
- Mechanical Stretch Promotes Macrophage Polarization and Inflammation via the RhoA-ROCK/NF-κB Pathway. | Tu, PC., et al. 2022. Biomed Res Int. 2022: 6871269. PMID: 35915804
- Calcium sensitization of smooth muscle mediated by a Rho-associated protein kinase in hypertension. | Uehata, M., et al. 1997. Nature. 389: 990-4. PMID: 9353125
- An essential part for Rho-associated kinase in the transcellular invasion of tumor cells. | Itoh, K., et al. 1999. Nat Med. 5: 221-5. PMID: 9930872
Inhibitor of:
Enzyme, PRK2, Rock-1, and Rock-2.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Y-27632 dihydrochloride, 1 mg | sc-281642 | 1 mg | $94.00 | |||
Y-27632 dihydrochloride, 10 mg | sc-281642A | 10 mg | $237.00 |