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WAVE2 Antibody (C-6) - Western Blotting - Image 146887
WAVE2 抗体 (C-6): sc-373889. MOLT-4 (A) 和 CCRF-CEM (B) 全细胞裂解液中 WAVE2 表达的 Western 印迹分析.
WAVE2 抗体 (C-6): sc-373889. MOLT-4 (A) 和 CCRF-CEM (B) 全细胞裂解液中 WAVE2 表达的 Western 印迹分析.

WAVE2 抗体 (C-6): sc-373889

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说明书
  • WAVE2 抗体 C-6 是小鼠单克隆 IgM κ，WAVE2抗体, 在7篇文献中引用，规格为200 µg/ml
  • 特异性抗原位于human物种的WAVE2的内部区域内的氨基酸177-206之间
  • 推荐用于WB, IP, IF和ELISA检测mouse, rat, human和来源的WAVE2; 也和以下物种反应，包括： 和 equine, canine, bovine and avian
  • 关于如何获取WAVE2 (C-6): sc-373889的免费10 µg小样，联系我们技术服务部门 (或者您当地的代理商)了解详情。
  • m-IgGκ BP-HRP是WAVE2 Antibody (C-6) 适用于 WB 应用。 的首选辅助检测试剂。该试剂现可与WAVE2 Antibody (C-6) 搭配使用（请参阅下面的订购信息）。有关其它 m-IgGκ BP 结合物，请参阅我们完整的小鼠 IgG 结合蛋白列表。

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関連項目

额外WAVE抗体，包括WAVE1, WAVE2和wave3

WAVE2抗体（C-6）是一种IgM κ小鼠单克隆WAVE2抗体（也称为WASP家族成员2抗体、WAVE2抗体、Wiskott-Aldrich综合征蛋白家族成员2抗体、含Verprolin同源结构域蛋白2抗体、WASP家族蛋白成员2抗体、WAS蛋白家族成员2抗体、SCAR2抗体、环磷酸腺苷受体抑制因子（WASP家族）抗体、WAS蛋白家族成员2抗体、WASP家族蛋白成员4抗体或WASF4抗体），可通过WB、IP、IF和ELISA检测小鼠、大鼠和人类来源的WAVE2蛋白。WAVE2抗体（C-6）以非偶联抗WAVE2抗体的形式提供。WASP（Wiskott-Aldrich综合征蛋白）和N-WASP是Cdc42的下游效应器，参与肌动蛋白聚合和细胞骨架组织。WASP家族还包括VASP（血管舒张刺激磷蛋白）和Mena（哺乳动物激活蛋白），它们聚集在粘着斑，也参与肌动蛋白细胞骨架的调节。WAVE蛋白与WASP家族蛋白相关，同样参与介导Rho家族小GTP酶下游的肌动蛋白重组。蛋白同源物WAVE1和WAVE2通过响应GTP结合和激活Rac来诱导肌动蛋白丝簇的形成，从而调节细胞膜褶皱。它们通过与Arp2/3复合物合作介导肌动蛋白聚合，从而促进肌动蛋白丝的形成。WAVE1也被称为SCAR（cAR抑制因子），主要在大脑中表达，而WAVE2则广泛表达，其中在外周血白细胞中的表达最高。WAVE3形成一个多蛋白复合物，将受体激酶与肌动蛋白连接起来，并在涉及细胞形状、功能或运动变化的信号转导中发挥作用。

仅限研究使用。不适用于诊断和治疗用途。

Alexa Fluor® 是Molecular Probes Inc., OR., USA的商标

LI-COR®和 Odyssey® 是LI-COR Biosciences的注册商标

WAVE2 抗体 (C-6) 参考文献:

  1. Scar是一种与WASp相关的蛋白质，它通过Arp2/3复合物激活肌动蛋白丝的成核。  |  Machesky, LM., et al. 1999. Proc Natl Acad Sci U S A. 96: 3739-44. PMID: 10097107
  2. N-WASP 与 Arp2/3 复合物之间的相互作用将 Cdc42 依赖性信号与肌动蛋白组装联系起来。  |  Rohatgi, R., et al. 1999. Cell. 97: 221-31. PMID: 10219243
  3. 启用/VASP 同源物 1 结构域-肽复合物的结构：肌动蛋白组装空间控制的关键组成部分。  |  Prehoda, KE., et al. 1999. Cell. 97: 471-80. PMID: 10338211
  4. 确定两个人类 WAVE/SCAR 同源物是与 Arp2/3 复合物相关联的一般肌动蛋白调节分子。  |  Suetsugu, S., et al. 1999. Biochem Biophys Res Commun. 260: 296-302. PMID: 10381382
  5. 系统分析显示 WAVE2 复合物与发育性左侧阻塞性心脏缺陷的发病机制有关  |  Edwards, JJ., et al. 2020. JACC Basic Transl Sci. 5: 376-386. PMID: 32368696
  6. WAVE2 信号在癌症中的作用  |  Rana, PS., et al. 2021. Biomedicines. 9: PMID: 34572403
  7. WAVE2 调节 B 细胞抗原受体和整合素诱导的肌动蛋白依赖过程  |  Bedi, A., et al. 2023. Cells. 12: PMID: 38067132
  8. WAVE2是通过机械敏感性MRTFA-SRF轴调节原代细胞生肌分化的生机论  |  Nguyen, MT., et al. 2023. Cells. 13: PMID: 38201213
  9. 维斯科特-阿尔德里奇综合征蛋白是 GTPase CDC42Hs 的一种新型效应物，与肌动蛋白聚合反应有关。  |  Symons, M., et al. 1996. Cell. 84: 723-34. PMID: 8625410
  10. SCAR是一种与WASP相关的蛋白质，被分离出来作为竹荪发育后期受体缺陷的抑制因子。  |  Bear, JE., et al. 1998. J Cell Biol. 142: 1325-35. PMID: 9732292
  11. WAVE，一种参与 Rac 诱导的肌动蛋白重组的新型 WASP 家族蛋白。  |  Miki, H., et al. 1998. EMBO J. 17: 6932-41. PMID: 9843499
  12. Scar1 和相关的 Wiskott-Aldrich 综合征蛋白（WASP）通过 Arp2/3 复合物调节肌动蛋白细胞骨架。  |  Machesky, LM. and Insall, RH. Curr Biol. 8: 1347-56. PMID: 9889097

订购信息

产品名称产品编号规格价格数量收藏夹

WAVE2 抗体 (C-6)

sc-373889
200 µg/ml
$316.00

WAVE2 (C-6): m-IgGκ BP-HRP 套装

sc-522543
200 µg Ab, 40 µg BP
$354.00

WAVE2 (C-6) 中和勝肽

sc-373889 P
100 µg/0.5 ml
$68.00

What application is the blocking peptide sc-373889 P appropriate for?

Asked by: cjMara
Thank you for your question. The blocking peptide is intended for use as a negative control, by pre-adsorbing the mouse monoclonal antibody against the antigen. For full protocol details, please contact our Technical Services Department or view our online protocol here: https://www.scbt.com/scbt/resources/protocols/peptide-neutralization
Answered by: Technical Support
Date published: 2017-02-24
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Rated 4 out of 5 by from WAVE2 Antibodies (C-6): sc-373889 work in WB and aImage shows analysis of WAVE2 level in LN229 cells upon CRISPR-Cas9-mediated KO WAVE2 using two different gRNAs. WAVE2 Antibodies (C-6): sc-373889 detect a band of approximately 84 kDa (corresponding to molecular weight of WAVE2) and are specific.
Date published: 2020-07-31
Rated 1 out of 5 by from Does not work!Used for WB with a 1:300 dilution in SUM159, A7r5, Caco-2 and 293T cell lysates. No signal at all.
Date published: 2017-11-15
Rated 1 out of 5 by from No banding in rangeThere were no detectable bands within the expected range in U2OS cells.
Date published: 2017-07-31
Rated 5 out of 5 by from Western blotWestern blot we obtained a right band arount 90kda, 1：600 dilution for WB.
Date published: 2017-05-28
Rated 5 out of 5 by from specific bandShowing only one specific band on western blot for HepG2 cell. Dilution is 1:1000.
Date published: 2017-05-28
Rated 5 out of 5 by from specific bandsThe specific bands were detected by Western blot and 1:500 in mouse tissues,strong target band at 90kda.
Date published: 2017-05-27
Rated 5 out of 5 by from Good product.The analysis results of Western blot were very strong and clear.Good product.
Date published: 2017-04-28
Rated 5 out of 5 by from Good antibody for IFI used to work with the H-110 clone but as it has been discontinued, I asked for a free sample of this antibody. The picture presented on the website was not highly convincing as WAVE2 should be enriched at the leading edge. Although, I was really surprised because I have got a very good localisation in my cells. I have tested both antibodies in parallel and for the same dilution (1:50), signal was weaker for the C-6 clone but much cleaner.
Date published: 2017-03-15
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WAVE2 抗体 (C-6) is rated 4.2 out of 5 by 11.
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