VU 0364439 (CAS 1246086-78-1)
Application:
VU 0364439 is a positive allosteric modulator (PAM) of mGluR-4
CAS Number:
1246086-78-1
Molecular Weight:
422.29
Molecular Formula:
C18H13Cl2N3O3S
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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Description
Technical Information
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SDS & Certificate of Analysis
VU 0364439 is a positive allosteric modulator (PAM) of mGluR-4 (metabotropic glutamate receptor) (EC50 = 19.8 nM in vitro for human mGluR-4).
VU 0364439 (CAS 1246086-78-1) References
- Synthesis and SAR of novel, 4-(phenylsulfamoyl)phenylacetamide mGlu4 positive allosteric modulators (PAMs) identified by functional high-throughput screening (HTS). | Engers, DW., et al. 2010. Bioorg Med Chem Lett. 20: 5175-8. PMID: 20667732
- Solution-phase parallel synthesis and SAR of homopiperazinyl analogs as positive allosteric modulators of mGlu₄. | Cheung, YY., et al. 2011. ACS Comb Sci. 13: 159-65. PMID: 21338051
- Recent advances in the drug discovery of metabotropic glutamate receptor 4 (mGluR4) activators for the treatment of CNS and non-CNS disorders. | Célanire, S. and Campo, B. 2012. Expert Opin Drug Discov. 7: 261-80. PMID: 22468956
- Recent progress on the identification of metabotropic glutamate 4 receptor ligands and their potential utility as CNS therapeutics. | Robichaud, AJ., et al. 2011. ACS Chem Neurosci. 2: 433-49. PMID: 22860170
- Metabotropic glutamatergic receptors and their ligands in drug addiction. | Pomierny-Chamioło, L., et al. 2014. Pharmacol Ther. 142: 281-305. PMID: 24362085
- Overlapping binding sites drive allosteric agonism and positive cooperativity in type 4 metabotropic glutamate receptors. | Rovira, X., et al. 2015. FASEB J. 29: 116-30. PMID: 25342125
- GRM4 inhibits the proliferation, migration, and invasion of human osteosarcoma cells through interaction with CBX4. | Zhang, Z., et al. 2020. Biosci Biotechnol Biochem. 84: 279-289. PMID: 31581881
- New 1,2,4-oxadiazole derivatives with positive mGlu4 receptor modulation activity and antipsychotic-like properties. | Stankiewicz, A., et al. 2022. J Enzyme Inhib Med Chem. 37: 211-225. PMID: 34894953
- Advancement of PI3 Kinase Inhibitor Combination Therapies for PI3K-Aberrant Chordoma. | Heft Neal, ME., et al. 2022. J Neurol Surg B Skull Base. 83: 87-98. PMID: 35155075
Activator of:
mGluR-4.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
VU 0364439, 10 mg | sc-364720 | 10 mg | $159.00 | |||
VU 0364439, 50 mg | sc-364720A | 50 mg | $795.00 |