Every item is shipped based on the best shipping method assessed for the temperature requirements of that specific item. Items are grouped and shipped together whenever
possible, and a separate shipping charge will be included for each shipping method required. Shipping charges listed below are from our US warehouses to the Contiguous US,
Alaska, Hawaii, Canada and Puerto Rico. Shipping charges for countries outside the US and Canada will be determined once order has been received
Please note: We can not ship to PO boxes
Express Blue Ice
Express Dry Ice
Animal Health Prescription Item
SHIPPING METHODS & CHARGES
Ships via FedEx Ground to Contiguous US, Alaska, Canada, Monday through Friday. This method is used for less temperature sensitive items such as lab ware and animal
health products, bulky and/or heavy items
Labware ships FedEx Ground free of charge to the contiguous US
Class E vacuolar protein sorting (vps) proteins are necessary for the appropriate sorting of receptors in the yeast endocytic pathway. Yeast Vps4p is a member of the AAA protein family (ATPases associated with diverse cellular activities) and plays an important role in transporting proteins out of prevacuolar endosomal compartments. In humans, two non-allelic orthologous proteins, VPS4A and VPS4B, are known and can form heteromeric complexes with each other. Both VPS4A and VPS4B are class E VPSs and are involved in intracellular protein trafficking, similar to Vps4p in yeast. HIV-1 uses cellular machinery to bud from infected cells and requires the two human VPS4 proteins and tsg 101 (tumor susceptibility gene 101) for this budding process. Dominant negative mutants of VPS4 proteins inhibit vacuolar protein sorting and also arrest HIV-1 and MLV budding. Thus, retroviruses normally use the VPS pathway to form multivesicular bodies during the budding process.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences