UBP 282 CAS: 544697-47-4
MF: C15H15N3O6
MW: 333.3
A receptor antagonist that distinguishes between motoneuron and dorsal root kainate receptors.

UBP 282 (CAS 544697-47-4)

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备用名: 3-CBW; (αS)-α-Amino-3-[(4-carboxyphenyl)methyl]-3,4-dihydro-2,4-dioxo-1(2H)-pyrimidinepropanoic acid
应用; UBP 282 is a receptor antagonist that distinguishes between motoneuron and dorsal root kainate receptors
CAS号码: 544697-47-4
纯度: >98%
分子量: 333.3
分子式: C15H15N3O6
仅供科研使用。不可用于诊断或治疗。
* 参考分析证明 大量特定数据 (包括水 含量).

UBP 282 is an GluR (AMPA and kainate receptor) antagonist that distinguishes between motoneuron and dorsal root kainate receptors. Inhibits AMPA receptor-, but not kainate receptor-mediated currents on spinal neonatal motoneurons yet antagonizes kainate-induced responses on dorsal root C-fibres. AMPA is a transmembrane glutamate receptor composed of the subunits GluR-1,2,3,4.


参考文献

1. More, J.C., et al. 2002. Br. J. Pharmacol. 137: 1125-1133.
2. More, J.C., et al. 2003. Br. J. Pharmacol. 138: 1093-1100.

物理状态 :
Solid
溶解度 :
Soluble in 1eq. NaOH (100 mM), and 1eq. HCl (25 mM).
保存 :
Store at room temperature
熔点 :
327.83° C (Predicted)
沸点 :
~612.6° C at 760 mmHg (Predicted)
密度 :
~1.5 g/cm3 (Predicted)
折射率 :
n20D 1.66 (Predicted)
IC50 :
Glutamate receptor ionotropic, AMPA: IC50 = 10.3 µM (rat)
Ki 数据 :
Glutamate receptor ionotropic, AMPA: Ki= 13.4 µM (rat); Glutamate receptor ionotropic kainate 2: Ki>100 µM (rat)
pK值 :
pKa: 2.12 (Predicted), pKb: 9.03 (Predicted)
仅供科研使用。不可用于诊断或治疗。
PubChem CID :
MDL 号码 :
MFCD06411590
SMILES :
C1=CC(=CC=C1CN2C(=O)C=CN(C2=O)C[[email protected]@H](C(=O)O)N)C(=O)O

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