U2 snRNP A Antibody (E-12): sc-390770
- U2 snRNP A Antibody (E-12) is a mouse monoclonal IgG1 κ provided at 200 µg/ml
- specific for an epitope mapping between amino acids 18-39 of U2 snRNP A of human origin
- recommended for detection of U2 snRNP A of mouse, rat, human and avian origin by WB, IP, IF, IHC(P) and ELISA; also reactive with additional species, including and equine, canine, bovine, porcine and avian
- m-IgG Fc BP-HRP and m-IgG1 BP-HRP are the preferred secondary detection reagents for U2 snRNP A Antibody (E-12) for WB and IHC(P) applications. These reagents are now offered in bundles with U2 snRNP A Antibody (E-12) (see ordering information below).
QUICK LINKS
U2 snRNP A Antibody (E-12) is a mouse monoclonal IgG1 antibody that detects U2 snRNP A in mouse, rat, and human samples through various applications including western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry with paraffin-embedded sections (IHCP), and enzyme-linked immunosorbent assay (ELISA). U2 snRNP A, also known as SNRPA1 or U2A, plays a crucial role in pre-mRNA splicing by forming part of the U2 small nuclear ribonucleoprotein complex, which is essential for spliceosome assembly. Spliceosomes remove introns from pre-mRNA, a vital process for producing mature mRNA that translates into functional proteins. U2 snRNP A interacts with U2 snRNP B to create a dimer that binds to U2 snRNA hairpin IV, a critical step in the splicing mechanism. The structural configuration of this dimer, along with specific variations in key residues, determines binding specificity of the snRNP to RNA, influencing pre-mRNA splicing efficiency and accuracy. U2 snRNP A consists of 255 amino acids and exists in two isoforms due to alternative splicing, highlighting the complexity and regulatory potential in gene expression.
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
U2 snRNP A Antibody (E-12) | sc-390770 | 200 µg/ml | $322.00 | |||
U2 snRNP A Antibody (E-12): m-IgG Fc BP-HRP Bundle | sc-540850 | 200 µg Ab; 10 µg BP | $361.00 | |||
U2 snRNP A Antibody (E-12): m-IgG1 BP-HRP Bundle | sc-542415 | 200 µg Ab; 20 µg BP | $361.00 | |||
U2 snRNP A (E-12) Neutralizing Peptide | sc-390770 P | 100 µg/0.5 ml | $69.00 |