Date published: 2025-9-7

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TSG-6 抗体 (A38.1.20): sc-65886

3.8(4)
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说明书
  • TSG-6 抗体 A38.1.20 是大鼠单克隆 IgG2a, 在18篇文献中引用,提供 200 µg/ml
  • 针对表达human来源的CD44:TSG嵌合物的CTLL-2细胞系
  • 抗-TSG-6 抗体 (A38.1.20) 推荐用于 WB, IP, IF, IHC(P) 和 ICF,检测mouse, rat 和human 来源的 TSG-6
  • 抗TSG-6抗体(A38.1.20)可与琼脂糖结合用于IP;与HRP结合用于WB、IHC(P)和ELISA;与藻红蛋白FITC结合用于IF、IHC(P)和FCM
  • 还可偶联Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594Alexa Fluor® 647,用于WB (RGB), IF, IHC(P) 和 FCM, 以及用于RGB荧光成像系统,例如iBright™ FL1000, FluorChem™, Typhoon, Azure和其他类似的系统
  • 还可偶联Alexa Fluor® 680Alexa Fluor® 790, 用于WB (NIR), IF 和 FCM; 以及用于近红外(NIR)检测系统,如LI-COR®/Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure和类似系统
  • 关于如何获取TSG-6 (A38.1.20): sc-65886免费10 µg小样,联系我们技术服务部门 (或者您当地的代理商)了解详情。
  • 目前,我们还没有完成TSG-6 抗体 (A38.1.20)的首选二抗检测试剂的鉴定。这项工作正在进行中。

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関連項目

TSG-6 抗体(A38.1.20)是一种大鼠单克隆 IgG2a 抗体,设计用于检测小鼠、大鼠和人体内的 TSG-6(又称 TNF 刺激基因 6 或肿瘤坏死因子诱导基因 6 蛋白)。TSG-6 是一种重要的糖蛋白,参与炎症和细胞外基质稳定性的调节,在伤口愈合和类风湿性关节炎的发病机制等过程中发挥重要作用。抗 TSG-6 抗体(A38.1.20)以表达人源 CD44 嵌合体的 CTLL-2 细胞系为靶标,可确保强效结合和检测。TSG-6 的功能是与透明质酸相互作用,并与α间抑制因子(IαI)的成分形成稳定的复合物,从而增强对蛋白酶活性的抑制,并调节蛋白酶网络以抑制炎症反应。TSG-6 基因在正常成纤维细胞中转录活跃,并在 TNFα 和 IL-1 等促炎细胞因子的作用下上调,这凸显了它在免疫反应和组织重塑中的重要性。TSG-6 单克隆抗体(A38.1.20)用途广泛,适用于免疫印迹(WB)、免疫沉淀(IP)、免疫荧光(IF)、石蜡包埋切片免疫组化(IHCP)和流式细胞术(FCM)。TSG-6 (A38.1.20) 抗体有非共轭型和多种共轭型,包括辣根过氧化物酶 (HRP)、藻红蛋白 (PE)、异硫氰酸荧光素 (FITC) 和多种 Alexa Fluor® 变体,可灵活满足不同的实验需求。TSG-6 与粘附受体 CD44 高度同源,尤其是在透明质酸结合域,这突出了它在研究细胞粘附和迁移方面的重要性。抗 TSG-6 抗体(A38.1.20)使研究人员能够有效地研究炎症和细胞外基质相互作用的复杂机制,因此是推进生物医学研究的重要工具。

仅限研究使用。不适用于诊断和治疗用途。

Alexa Fluor® 是Molecular Probes Inc., OR., USA的商标

LI-COR®和 Odyssey® 是LI-COR Biosciences的注册商标

TSG-6 抗体 (A38.1.20) 参考文献:

  1. 一种新型分泌型肿瘤坏死因子诱导蛋白(TSG-6)是透明质酸结合蛋白家族的成员,与粘附受体 CD44 关系密切。  |  Lee, TH., et al. 1992. J Cell Biol. 116: 545-57. PMID: 1730767
  2. TSG-6是一种与关节炎相关的透明质酸结合蛋白,它与血清蛋白α间阻抑剂形成稳定的复合物。  |  Wisniewski, HG., et al. 1994. Biochemistry. 33: 7423-9. PMID: 7516184
  3. NF-IL6和AP-1协同调节肿瘤坏死因子α和白细胞介素-1对TSG-6基因的激活。  |  Klampfer, L., et al. 1994. Mol Cell Biol. 14: 6561-9. PMID: 7935377
  4. TSG-6:与关节炎有关的 TNF, IL-1 和 LPS 诱导的分泌糖蛋白。  |  Wisniewski, HG., et al. 1993. J Immunol. 151: 6593-601. PMID: 8245487
  5. TSG6的转录调控,TSG6是肿瘤坏死因子和白细胞介素-1诱导的主要反应基因,编码一种分泌型透明质酸结合蛋白。  |  Lee, TH., et al. 1993. J Biol Chem. 268: 6154-60. PMID: 8454591

订购信息

产品名称产品编号规格价格数量收藏夹

TSG-6 抗体 (A38.1.20)

sc-65886
200 µg/ml
$316.00

TSG-6 抗体 (A38.1.20) AC

sc-65886 AC
500 µg/ml, 25% agarose
$416.00

TSG-6 抗体 (A38.1.20) HRP

sc-65886 HRP
200 µg/ml
$316.00

TSG-6 抗体 (A38.1.20) FITC

sc-65886 FITC
200 µg/ml
$330.00

TSG-6 抗体 (A38.1.20) PE

sc-65886 PE
200 µg/ml
$343.00

TSG-6 抗体 (A38.1.20) Alexa Fluor® 488

sc-65886 AF488
200 µg/ml
$357.00

TSG-6 抗体 (A38.1.20) Alexa Fluor® 546

sc-65886 AF546
200 µg/ml
$357.00

TSG-6 抗体 (A38.1.20) Alexa Fluor® 594

sc-65886 AF594
200 µg/ml
$357.00

TSG-6 抗体 (A38.1.20) Alexa Fluor® 647

sc-65886 AF647
200 µg/ml
$357.00

TSG-6 抗体 (A38.1.20) Alexa Fluor® 680

sc-65886 AF680
200 µg/ml
$357.00

TSG-6 抗体 (A38.1.20) Alexa Fluor® 790

sc-65886 AF790
200 µg/ml
$357.00

what is the quantity (in mL) associated with product sc-65886 (and understand it is 200 ug/mL).

Asked by: Aaron
Thank you for your question. TSG-6 Antibody (A38.1.20): sc-65886 is provided as 200 µg in 1 ml buffer.
Answered by: Tech Support Europe
Date published: 2025-07-02

Hi there, I am using the antibody sc-65886 (A38.1.20) for my binding assays to TSG-6 and I was wondering whether you are aware of the antibody epitope on TSG-6. I know that it binds the Link domain of TSG-6 but do you know the epitope sequence. Thank you

Asked by: Nikos
Thank you for your question. No epitope mapping has been performed for this antibody as of yet, so its binding site on the target protein is not known.
Answered by: Tech Support Europe
Date published: 2022-03-25

What is the recommended secondary reagent to be used with this mouse monoclonal primary?

Asked by: jerojero
We recommend using one our exclusive Mouse IgG Binding Proteins as a secondary detection reagent. A complete list of available binding proteins is available on our website here: https://www.scbt.com/scbt/browse/support-products-mouse-igg-binding-proteins/_/N-ecrety
Answered by: Technical Support 7
Date published: 2017-01-09
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Rated 4 out of 5 by from Ok productOk data but not near as good a product as the E-1 clone from scbt
Date published: 2017-01-06
Rated 5 out of 5 by from Western blot good resultClean band detected of human recombinant TSG-6 in western blot.
Date published: 2016-12-22
Rated 3 out of 5 by from Published results of ELISA using hMSCs andPublished results of ELISA using hMSCs and mouse MSCs. -SCBT Publication Review
Date published: 2015-02-28
Rated 3 out of 5 by from Slighlty faint positive in western blot usingSlighlty faint positive in western blot using human recombinant TSG-6. -SCBT QC
Date published: 2013-07-23
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TSG-6 抗体 (A38.1.20) is rated 3.8 out of 5 by 4.
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