TRAF1 Antibody (E-10): sc-514936

TRAF1 Antibody (E-10) is a mouse monoclonal IgG1 antibody that detects TRAF1 in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). TRAF1 plays a crucial role in the regulation of immune responses and cell survival by mediating signaling pathways initiated by various receptors, including the tumor necrosis factor receptor (TNF-R). TRAF1 is primarily located in the cytoplasm, where TRAF1 forms complexes with other signaling molecules, such as TRAF2, to propagate downstream signaling cascades that influence cell proliferation and apoptosis. The proper functioning of TRAF1 is vital for maintaining immune homeostasis, and dysregulation of TRAF1 activity has been implicated in various diseases, including autoimmune disorders and cancer. Anti-TRAF1 antibody (E-10) is an essential tool for researchers aiming to explore the intricate mechanisms of TNF receptor signaling and its implications in health and disease.

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TRAF1 Antibody (E-10) References:

1. TRAF1 regulates Th2 differentiation, allergic inflammation and nuclear localization of the Th2 transcription factor, NIP45.  |  Bryce, PJ., et al. 2006. Int Immunol. 18: 101-11. PMID: 16352630
2. TRAF1 phosphorylation on Serine 139 modulates NF-κB activity downstream of 4-1BB in T cells.  |  Oussa, NA., et al. 2013. Biochem Biophys Res Commun. 432: 129-34. PMID: 23376065
3. The Upregulation of TRAF1 Induced by Helicobacter pylori Plays an Antiapoptotic Effect on the Infected Cells.  |  Wan, XK., et al. 2016. Helicobacter. 21: 554-564. PMID: 27060717
4. Helicobacter pylori inhibits the cleavage of TRAF1 via a CagA-dependent mechanism.  |  Wan, XK., et al. 2016. World J Gastroenterol. 22: 10566-10574. PMID: 28082808
5. TRAF1 Is Critical for Regulating the BRAF/MEK/ERK Pathway in Non-Small Cell Lung Carcinogenesis.  |  Wang, Q., et al. 2018. Cancer Res. 78: 3982-3994. PMID: 29748372
6. Effect of TRAF1 on Phenotypic Changes Of Kupffer Cells In Liver Transplantation Ischemic-Reperfusion.  |  Zhang, Z., et al. 2021. Curr Pharm Biotechnol. 22: 1602-1611. PMID: 33430723
7. RNA demethylase ALKBH5 promotes tumorigenesis in multiple myeloma via TRAF1-mediated activation of NF-κB and MAPK signaling pathways.  |  Qu, J., et al. 2022. Oncogene. 41: 400-413. PMID: 34759347
8. Identification of a regulatory pathway governing TRAF1 via an arthritis-associated non-coding variant.  |  Wang, Q., et al. 2024. Cell Genom. 4: 100502. PMID: 38359789
9. Uncovering the Interaction between TRAF1 and MAVS in the RIG-I Pathway to Enhance the Upregulation of IRF1/ISG15 during Classical Swine Fever Virus Infection.  |  Zhang, L., et al. 2024. Cells. 13: PMID: 38995016
10. The methyltransferase METTL3 regulates endothelial cell proliferation and inflammation via m6A RNA methylation-mediated TRAF1 expression.  |  Chen, D., et al. 2024. Biochem Biophys Res Commun. 732: 150399. PMID: 39033551

The preferred TRAF1 antibody is TRAF1 Antibody (H-3): sc-6253.