TMS CAS: 24144-92-1
MF: C18H20O4
MW: 300.35
An inhibitor of cytochrome P450 1B1 and cancer cell growth.

TMS (CAS 24144-92-1)

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备用名: 2,3',4,5'-Tetramethoxystilbene; 1-[(1E)-2-(3,5-dimethoxyphenyl)ethenyl]-2,4-dimethoxy-benzene
应用; TMS is an inhibitor of cytochrome P450 1B1 and cancer cell growth
CAS号码: 24144-92-1
纯度: ≥98%
分子量: 300.35
分子式: C18H20O4
仅供科研使用。不可用于诊断或治疗。
* 参考分析证明 大量特定数据 (包括水 含量).
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TMS is a strong, selective and competitive inhibitor of cytochrome P450 1B1, an overexpressed enzyme in particular tumors (IC50 = 6 nM). 50- and 520-fold selective over P450 1A1 and 1A2 respectively. TMS inhibits cancer cell growth in vitro.


参考文献

1. Nam, K.A., et al. 2001. Arch. Pharm. Res. 24: 441-445.
2. Chun, Y.J., et al. 2001. Cancer Res. 61: 8164-8170.
3. Kim, S., et al. 2002. J. Med. Chem. 45: 160-164.

物理状态 :
Solid
溶解度 :
Soluble in ethanol (25 mM), DMSO (100 mM), water (0.5 mg/ml at 25° C), DMF (~20 mg/ml), and methanol.
保存 :
Store at -20° C
熔点 :
137.99° C (Predicted)
沸点 :
~459.9° C at 760 mmHg (Predicted)
密度 :
~1.1 g/cm3 (Predicted)
折射率 :
n20D 1.59 (Predicted)
IC50 :
Cell growth : IC50 = 0.8 nM (human lung carcinoma cells ); CYP1B1: IC50 = 6 nM (human); CYP1A1: IC50 = 300 nM (human); CYP1A2: IC50 = 3.1 µM (human); ADMET: IC50 = 5.6 µM
Ki 数据 :
CYP1B1: Ki= 3 nM
仅供科研使用。不可用于诊断或治疗。
PubChem CID :
MDL 号码 :
MFCD03428621
SMILES :
COC1=CC(=C(C=C1)/C=C/C2=CC(=CC(=C2)OC)OC)OC

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