TIM Antibody (BB-7): sc-100541
- TIM Antibody (BB-7) is a mouse monoclonal IgG1 κ, cited in 1 publications, provided at 100 µg/ml
- raised against recombinant TIM of human origin
- recommended for detection of TIM of mouse, rat and human origin by WB, IP, IF and ELISA
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for TIM Antibody (BB-7). This work is in progress.
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TIM Antibody (BB-7) is a mouse monoclonal IgG1 antibody that detects Triosephosphate Isomerase (TIM) in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). TIM is a crucial enzyme in the glycolytic pathway, facilitating the reversible conversion of dihydroxyacetone phosphate (DHAP) and glyceraldehyde-3-phosphate, which are essential intermediates in glucose metabolism. This enzymatic activity is vital for energy production, as TIM plays a key role in the generation of pyruvate and ATP from glucose, thereby supporting cellular respiration and energy homeostasis. TIM is predominantly located in the cytosol, where TIM participates in the glycolytic process, and proper functioning is critical for maintaining metabolic balance. Mutations or deficiencies in TIM can lead to significant metabolic disorders, including non-spherocytic hemolytic anemia and other serious health issues, underscoring TIM′s importance in both normal physiology and disease states. Anti-TIM antibody (BB-7) is an invaluable tool for researchers studying glycolysis and its implications in metabolic diseases.
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TIM Antibody (BB-7) References:
- The TIM-barrel fold: a versatile framework for efficient enzymes. | Wierenga, RK. 2001. FEBS Lett. 492: 193-8. PMID: 11257493
- The TIM gene family regulates autoimmune and allergic diseases. | Meyers, JH., et al. 2005. Trends Mol Med. 11: 362-9. PMID: 16002337
- TIM family of genes in immunity and tolerance. | Kuchroo, VK., et al. 2006. Adv Immunol. 91: 227-49. PMID: 16938542
- TIM gene family and their role in atopic diseases. | Umetsu, DT., et al. 2008. Curr Top Microbiol Immunol. 321: 201-15. PMID: 18727494
- The costimulatory role of TIM molecules. | Rodriguez-Manzanet, R., et al. 2009. Immunol Rev. 229: 259-70. PMID: 19426227
- The emerging role of the TIM molecules in transplantation. | Yeung, MY., et al. 2011. Am J Transplant. 11: 2012-9. PMID: 21906254
- The impact of the TIM gene family on tumor immunity and immunosuppression. | Baghdadi, M. and Jinushi, M. 2014. Cell Mol Immunol. 11: 41-8. PMID: 24336162
- Traditional Indian medicine (TIM) and traditional Korean medicine (TKM): aconstitutional-based concept and comparison. | Kang, YM., et al. 2017. Integr Med Res. 6: 105-113. PMID: 28664134
- TIM-3: An update on immunotherapy. | Zhao, L., et al. 2021. Int Immunopharmacol. 99: 107933. PMID: 34224993
- Novel Roles of the Tim Family in Immune Regulation and Autoimmune Diseases. | Liu, Y., et al. 2021. Front Immunol. 12: 748787. PMID: 34603337
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
TIM Antibody (BB-7) | sc-100541 | 100 µg/ml | $339.00 |