Thymoquinone CAS: 490-91-5
MF: C10H12O2
MW: 164.20
A phytochemical that inhibitis tumor angiogenesis.

Thymoquinone (CAS 490-91-5)

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备用名: 2-Isopropyl-5-methyl-1,4-benzoquinone
应用; Thymoquinone is a phytochemical that inhibitis tumor angiogenesis
CAS号码: 490-91-5
纯度: ≥98%
分子量: 164.20
分子式: C10H12O2
仅供科研使用。不可用于诊断或治疗。
* 参考分析证明 大量特定数据 (包括水 含量).
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Thymoquinone is a phytochemical compound that acts as an angiogenesis inhibitor. Possesses potential analgesic, anticonvulsant, and anticancer properties in vitro.


参考文献

1. Kundu, Juthika., et al., 2014. Thymoquinone induces heme oxygenase-1 expression in HaCaT cells via Nrf2/ARE activation: Akt and AMPKα as upstream targets. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. 65(): 18-26. PMID: 24355171
2. Aycan, Ilker Öngüç., et al., 2014. Thymoquinone treatment against acetaminophen-induced hepatotoxicity in rats. International journal of surgery (London, England). (): . PMID: 24389315
3. Ashour, Abdelkader E., et al., 2014. Thymoquinone suppression of the human hepatocellular carcinoma cell growth involves inhibition of IL-8 expression, elevated levels of TRAIL receptors, oxidative stress and apoptosis. Molecular and cellular biochemistry. (): . PMID: 24399465
4. Khan, Masood A., et al., 2014. Protective effect of thymoquinone on glucose or methylglyoxal-induced glycation of superoxide dismutase. International journal of biological macromolecules. 65C(): 16-20. PMID: 24412154
5. Siveen, Kodappully Sivaraman., et al., 2014. Thymoquinone overcomes chemoresistance and enhances the anticancer effects of bortezomib through abrogation of NF-κB regulated gene products in multiple myeloma xenograft mouse model. Oncotarget. (): . PMID: 24504138

外观 :
Powder or crystalline or crystalline powder or chunks
物理状态 :
Solid
溶解度 :
Soluble in ether, alcohol, water (0.87 mg/ml at 25° C), chloroform, and methanol.
保存 :
Store at room temperature
熔点 :
45-47° C (lit.)
沸点 :
230-232° C (lit.)
密度 :
1.07 g/cm3 (Predicted)
折射率 :
n20D 1.51 (Predicted)
IC50 :
HL-60: IC50 = 28 µM (human); HFF: IC50 = 33 µM (human); HT-29: IC50 = 47 µM (human)
仅供科研使用。不可用于诊断或治疗。
德国水公害等级 :
3
RTECS :
GU5330000
PubChem CID :
10281
MDL 号码 :
MFCD00001602
EC号码 :
207-721-1
Beilstein 注册 :
1939047
SMILES :
CC1=CC(=O)C(=CC1=O)C(C)C

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引用1 - 66

PMID: # 25719309  Periyanayagam, S. et al. 2015. Journal of basic and clinical physiology and pharmacology. 26: 623-32.

PMID: # 26171893  Khan, MS. et al. 2015. Phytotherapy research : PTR. 29: 1610-5.

PMID: # 25709021  Khan, MA. et al. 2015. International journal of biological macromolecules. 76: 203-8.

PMID: # 22206670  Lei, X. et al. 2012. Biochemical and biophysical research communications. 417: 864-8.

PMID: # 30589842  PLoS ONE. 13: e0208951.

PMID: # 31030489  Asian Pac. J. Cancer Prev. 20: 1153-1160.

引用1 - 66
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