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TGF beta Receptor 1/TGFBR1 抗体 (RM0016-3A11): sc-101574

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说明书
  • TGF beta Receptor 1/TGFBR1 抗体 RM0016-3A11 是大鼠单克隆 IgG2，TGF beta Receptor 1/TGFBR1抗体, 在24篇文献中引用，规格为50 µg/0.5 ml
  • 针对TGFβ RI的胞外结构域，源自mouse
  • 推荐用于 mouse 来源的TGFβ RI WB, IF 和 IHC(P)检测
  • 关于如何获取TGF beta Receptor 1/TGFBR1 (RM0016-3A11): sc-101574的免费10 µg小样，联系我们技术服务部门 (或者您当地的代理商)了解详情。
  • 目前，我们还没有完成TGF beta Receptor 1/TGFBR1 抗体 (RM0016-3A11)的首选二抗检测试剂的鉴定。这项工作正在进行中。

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描述
基因信息
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研究信息

関連項目

此外 TGF β Receptor 抗体包括 TGF β RI, TGF β RII 和 TGF β RIII

TGFβ RI抗体（RM0016-3A11）是一种IgG2大鼠单克隆TGF beta RI抗体（也称为TGFBR1抗体、转化生长因子beta受体1抗体或ALK5抗体），可通过WB、IF和IHC(P)检测小鼠来源的TGF beta RI蛋白。TGFβ RI抗体（RM0016-3A11）为非偶联形式的抗TGF beta RI抗体。在哺乳动物中，已发现三种TGFβ家族成员，即TGFβ1、TGFβ2和TGFβ3。它们均以潜在前体的形式合成，随后裂解形成含有112个氨基酸的生长因子，该生长因子在二聚化后具有活性。TGFβ通过与含有胞质丝氨酸-苏氨酸激酶结构域的TGFβ受体II型（TGFβ RII）高亲和力结合来发挥其作用。为了传递生长抑制信号和早期基因反应，TGFβ RII既需要其激酶活性，又需要其与一种名为TGFβ受体1型（TGFβ RI）的TGFβ结合蛋白相关联。TGFβ RI是一种由503个氨基酸组成的单次跨膜I型膜蛋白，在体内普遍表达，并与TGFβ RII一起作为TGFβ的受体。编码TGFβ RI的基因缺陷是主动脉瘤家族性胸型5（AAT5）、Loeys-Dietz综合征2A型（LDS2A）和Loeys-Dietz综合征1A型（LDS1A）的致病原因。

仅限研究使用。不适用于诊断和治疗用途。

Alexa Fluor® 是Molecular Probes Inc., OR., USA的商标

LI-COR®和 Odyssey® 是LI-COR Biosciences的注册商标

TGF beta Receptor 1/TGFBR1 抗体 (RM0016-3A11) 参考文献:

  1. TGF-beta 家族的受体。  |  Massagué, J. 1992. Cell. 69: 1067-70. PMID: 1319842
  2. TGF beta 通过异构蛋白激酶受体复合物发出信号。  |  Wrana, JL., et al. 1992. Cell. 71: 1003-14. PMID: 1333888
  3. 通过抑制乳腺癌细胞中的组蛋白去乙酰化酶活性诱导受体RI，恢复转化生长因子-β信号。  |  Ammanamanchi, S. and Brattain, MG. 2004. J Biol Chem. 279: 32620-5. PMID: 15155736
  4. 不同的转化生长因子-β（TGF-β）受体亚群是细胞对三种 TGF-beta 异构体反应的决定因素。  |  Cheifetz, S., et al. 1990. J Biol Chem. 265: 20533-8. PMID: 1700790
  5. TGF-β-RI激酶抑制剂SD-208可减少黑色素瘤骨转移的发生和发展。  |  Mohammad, KS., et al. 2011. Cancer Res. 71: 175-84. PMID: 21084275
  6. 鉴定转化生长因子β型基因家族的另一个成员。  |  ten Dijke, P., et al. 1988. Proc Natl Acad Sci U S A. 85: 4715-9. PMID: 3164476
  7. 以 TGF-β RI 为靶点的天南星和莪术肺纤维化抑制剂的硅学研究。  |  Annam, N., et al. 2023. J Biomol Struct Dyn. 41: 3145-3161. PMID: 35068362
  8. 利用高分辨质谱法和硅学策略从何首乌中发现针对 TGF-β RI 的肺纤维化抑制剂。  |  Xu, H., et al. 2022. J Pharm Anal. 12: 860-868. PMID: 36605575
  9. 人类转化生长因子-β互补 DNA 序列及在正常细胞和转化细胞中的表达。  |  Derynck, R., et al. Nature. 316: 701-5. PMID: 3861940
  10. 来自病毒转化细胞条件培养基的肉瘤生长因子由α型和β型转化生长因子组成。  |  Anzano, MA., et al. 1983. Proc Natl Acad Sci U S A. 80: 6264-8. PMID: 6604914
  11. 鉴定与 II 型受体形成异构激酶复合物的人类活化素和 TGF beta I 型受体。  |  Attisano, L., et al. 1993. Cell. 75: 671-80. PMID: 8242742
  12. 克隆与 TGF beta II 型受体形成异构复合物的 TGF beta I 型受体。  |  Franzén, P., et al. 1993. Cell. 75: 681-92. PMID: 8242743

订购信息

产品名称产品编号规格价格数量收藏夹

TGF beta Receptor 1/TGFBR1 抗体 (RM0016-3A11)

sc-101574
50 µg/0.5 ml
$316.00

May I have a sample of it? I tried several Ab's none of them worked. I just want to test if it works and later order it.

Asked by: Bita
Thank you for your question. We do not offer this antibody, TGFβ RI (RM0016-3A11): sc-101574, in a sample size. The antibody is warrantied for one year for our recommended applications and species. If you choose the purchase the antibody and it does not perform for you as expected, please contact our Technical Service Department and we are happy to help you troubleshoot the antibody, and provide a complimentary replacement antibody or refund of your purchase if necessary.
Answered by: Technical Support
Date published: 2017-09-27

I need to use an antibody to detect the protein in samples of equine origin. Do you know if this mouse monoclonal antibody will work?

Asked by: jerojero
Please contact our Technical Service Department and we would be happy to perform sequence analysis and review our data to answer any questions you may have about additional species reactivity.
Answered by: Technical Support 2
Date published: 2017-02-17
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Rated 1 out of 5 by from TGFβ RI Antibody (RM0016-3A11) - Didn't work.Unfortunately the trial sample did not work on human cells (with knock-down controls) compared to an alternate validated TGFBR1 antibody.
Date published: 2018-01-22
Rated 1 out of 5 by from TGFβ RI Antibody (RM0016-3A11) reviewI used whole heart homogenates of hypetrophic hearts, hoping I could see an increase of TGFβ RI. This antibody give you several non specific bands.
Date published: 2017-12-05
Rated 5 out of 5 by from Strong and cleanWorks in Western blot with mouse primary mammary gland tissue, there is a clear band. 1:500 dilution is sufficient.
Date published: 2017-02-11
Rated 5 out of 5 by from ExcellentThis antibody was used to evaluate the role of miR-200b expression in the proliferation of human Tenon's capsule fibroblasts (HTFs) induced by transforming growth factor-beta 1
Date published: 2017-01-20
Rated 4 out of 5 by from Good data obtained by IHC using human colonGood data obtained by IHC using human colon adenocarcinoma tissue. -SCBT Publication Review
Date published: 2015-02-15
Rated 4 out of 5 by from Publishable data obtained by WB using mousePublishable data obtained by WB using mouse primary mammary gland tissue. -SCBT Publication Review
Date published: 2013-07-17
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TGF beta Receptor 1/TGFBR1 抗体 (RM0016-3A11) is rated 3.3 out of 5 by 6.
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