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T-type Ca<sup>++</sup> CP &alpha;1I Antibody (3H5) - Western Blotting - Image 348981
T 型 Ca++ CP α1I (3H5): sc-293486. 人重组 T 型 Ca++ CP α1I 融合蛋白的 Western 印迹分析.
T-type Ca++ CP α1I Antibody (3H5) - Western Blotting - Image 348981
T 型 Ca++ CP α1I (3H5): sc-293486. 人重组 T 型 Ca++ CP α1I 融合蛋白的 Western 印迹分析.
T 型 Ca++ CP α1I (3H5): sc-293486. 人重组 T 型 Ca++ CP α1I 融合蛋白的 Western 印迹分析.

T-type Ca++ CP α1I 抗体 (3H5): sc-293486

5.0(1)
寫評論提問

说明书
  • T-type Ca++ CP alpha 1I 抗体 3H5 是小鼠单克隆 IgG1 (kappa轻链)，T-type Ca++ CP α1I抗体，规格为100 µg/ml
  • 针对氨基酸233-331的抗原，代表human起源的部分长度T型Ca++ CP α1I
  • 推荐用于 mouse, rat 和 human 来源的T-type Ca++ CP α1I WB, IP 和 ELISA检测
  • 目前，我们还没有完成T-type Ca++ CP α1I 抗体 (3H5)的首选二抗检测试剂的鉴定。这项工作正在进行中。

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    描述
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    说明书与实验方案

    関連項目

    此外 Calcium Channel Protein 抗体包括 L-type Ca++ CP α 1F, L-type Ca++ CP α 1S, L-type Ca++ CP β 1A, L-type Ca++ CP β 2, L-type Ca++ CP β 3, L-type Ca++ CP β 4, L-type Ca++CP γ 2, L-type Ca++CP γ 3, L-type Ca++CP γ 8 和 N-type Ca++ CP α 1B

    T型钙离子通道α1I抗体（3H5）是一种小鼠单克隆IgG1κ轻链抗体，可通过蛋白质印迹（WB）、免疫沉淀（IP）和酶联免疫吸附测定（ELISA）检测小鼠、大鼠和人类来源的T型钙离子通道α1I蛋白。抗T型钙离子通道α1I抗体（3H5）以非结合形式提供。T型钙离子通道α1I蛋白在调节兴奋性细胞中的钙离子流入方面发挥着至关重要的作用，对于肌肉收缩、神经递质释放和基因表达等多种生理过程至关重要。T型钙离子通道α1I主要位于神经元和肌肉细胞的质膜上，是具有独特生物物理特性的电压依赖性钙离子通道家族的一部分。与其他钙通道类型相比，T型通道在更负的膜电位下快速激活和失活，有助于神经元产生动作电位和有节奏的放电。T型通道通过降低嗅觉感受器细胞中的脉冲产生阈值，增强嗅觉等感官知觉。了解T型钙离子通道CPα1I的功能和动态对于阐明其在正常生理和病理条件下的作用至关重要，这使得T型钙离子通道CPα1I（3H5）单克隆抗体成为研究钙信号传导通路的研究人员的重要工具。

    仅限研究使用。不适用于诊断和治疗用途。

    Alexa Fluor® 是Molecular Probes Inc., OR., USA的商标

    LI-COR®和 Odyssey® 是LI-COR Biosciences的注册商标

    T-type Ca++ CP α1I 抗体 (3H5) 参考文献:

    1. 电压门控 Ca2+ 通道的结构和调节。  |  Catterall, WA. 2000. Annu Rev Cell Dev Biol. 16: 521-55. PMID: 11031246
    2. T型Ca2+电流增强嗅觉受体细胞对气味的敏感性  |  Kawai, F. and Miyachi, E. 2001. J Neurosci. 21: RC144. PMID: 11319242
    3. T型钙离子通道和局部血流量的自动调节。  |  Jensen, LJ., et al. 2017. Channels (Austin). 11: 183-195. PMID: 28055302
    4. T型钙离子通道：T代表可靶向。  |  Sallán, MC., et al. 2018. Cancer Res. 78: 603-609. PMID: 29343521
    5. Cav3 T型电压门控钙离子通道与淀粉样环境：病理生理学以及对药物治疗和药物警戒的影响。  |  Papazoglou, A., et al. 2022. Int J Mol Sci. 23: PMID: 35408817
    6. 黄体酮对浦肯野细胞中T型钙通道表达的影响。  |  Eickhoff, A., et al. 2022. Neural Regen Res. 17: 2465-2471. PMID: 35535898
    7. T型Ca2+通道促进哺乳动物锥体感光细胞的神经传递。  |  Davison, A., et al. 2022. J Neurosci. 42: 6325-6343. PMID: 35803735
    8. T 型 Ca2+ 通道在调节背根神经节神经元的兴奋性方面发挥着双重作用。  |  Zhu, T. and Wang, Y. 2022. Mol Pain. 18: 17448069221132224. PMID: 36163701
    9. L型和T型Ca2+通道在实验性青光眼中对视网膜神经节细胞损伤有双重作用。  |  Wang, HN., et al. 2023. Neural Regen Res. 18: 1570-1577. PMID: 36571364
    10. T型钙离子通道介导了成体颗粒细胞可塑性关键期的形成。  |  Kennedy, WM., et al. 2024. J Neurosci. 44: PMID: 38413230
    11. 钙通道的分子生物学。  |  Perez-Reyes, E. and Schneider, T. 1995. Kidney Int. 48: 1111-24. PMID: 8569073
    12. 电压门控 Ca2+ 通道多样性的分子基础：现在是 T 的时候了吗？  |  Randall, AD. 1998. J Membr Biol. 161: 207-13. PMID: 9493126

    订购信息

    产品名称产品编号规格价格数量收藏夹

    T-type Ca++ CP α1I 抗体 (3H5)

    sc-293486
    100 µg/ml
    		$316.00

    Do we need different protein extraction method for this antibody. T type Ca channel is a membrane protein could we use standart protocol?

    Asked by: dancer81
    Thank you for your inquiry. We would recommend to follow the sample preparation according to the procedure described in the protocol for Western Blotting. Please find the protocol under the following link: https://www.scbt.com/scbt/resources/protocols/western-immuno-blotting?&amp;_requestid=3815318 For any further questions you may have please contact our Technical Service in our European Support Office in Germany directly. You can reach us by phone at: +49 6221 4503 0, by email at: europe@scbt.com or by live chat on our website, www.scbt.com We are happy to assist you.
    Answered by: Technical Support Europe
    Date published: 2018-01-19

    For Western Blot, is it recommended to use denatured or non-denatured conditions with T-type Ca++ CP &alpha;1I (3H5): sc-293486 antibody?

    Asked by: jerojero
    Thank you for your question. We recommend this antibody for use in denatured Western Blot conditions. It has not been validated for use in non-denatured conditions. Please contact our Technical Service Department for further details or inquiries.
    Answered by: Technical Support
    Date published: 2017-03-27
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    Rated 5 out of 5 by from Good for Western blotAntibody detects human recombinant T-type Ca++ CP α1I by Western blot. -SCBT QC
    Date published: 2023-09-14
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    T-type Ca ++ CP α1I 抗体 (3H5) is rated 5.0 out of 5 by 1.
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