syncollin Antibody (C-1): sc-376930

Syncollin Antibody (C-1) is a mouse monoclonal IgG2b antibody that detects syncollin in human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Syncollin, also known as SYL or insulin synthesis-associated protein 1, is a 134 amino acid protein predominantly expressed in pancreatic acinar cells, where syncollin localizes to the secretory vesicle membranes of cytoplasmic vesicles and the lumenal side of peripheral membranes. This strategic localization is crucial as syncollin facilitates the process of exocytosis, thereby influencing the maturation and concentration of zymogens within zymogen granules, which are essential for proper digestive enzyme secretion. The gene encoding syncollin is located on human chromosome 19, a region notable for its high gene density, housing approximately 1,400 genes, including various members of the immunoglobulin superfamily. The presence of syncollin in pancreatic acinar cells underscores syncollin′s importance in digestive health, as any dysregulation could lead to impaired enzyme secretion and subsequent digestive disorders. Anti-syncollin antibody (C-1) is an invaluable tool for researchers investigating the role of syncollin in pancreatic function and related pathologies.

The preferred syncollin antibody is syncollin Antibody (A-7): sc-376810.