Suppressin Antibody (F-7): sc-515174

Suppressin Antibody (F-7) is a mouse monoclonal IgG1 antibody that detects Suppressin in human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Suppressin, also known as DEAF1, SPN, NUDR, or ZMYND5, is a crucial transcription factor involved in embryonic development, containing a SAND domain and a C-terminal MYND-type zinc finger that facilitate regulatory functions. Suppressin is primarily localized in the nucleus, where anti-Suppressin antibody (F-7) can detect significant roles in mediating cell fate and embryonic pattern formation through interactions with other proteins such as LMO4 and CLIM-2. Nuclear localization of Suppressin allows for precise regulation of gene expression necessary for proper development. Several isoforms of Suppressin arise from alternative splicing, with some being secreted by specific cell types. Secreted Suppressin has been shown to inhibit cell proliferation, effectively arresting cells in the G0 or G1 phase of the cell cycle. Mutations in the gene encoding Suppressin can confer a growth advantage to cells, potentially leading to neoplasia, which highlights Suppressin′s relevance as a target for cancer therapy. Anti-Suppressin antibody (F-7) serves as an essential tool for researchers investigating developmental and disease roles.

The preferred Suppressin antibody is Suppressin Antibody (E-5): sc-514180.