Date published: 2025-9-10

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Sulfiredoxin 抗体 (B-4): sc-373829

5.0(3)
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说明书
  • Sulfiredoxin抗体(B-4)是小鼠单克隆IgG2b κ, 在1篇文献中引用,规格为200 µg/ml
  • 针对氨基酸1-137的抗原,代表全长Sulfiredoxin,来源于human
  • 推荐用于 human 来源的Sulfiredoxin WB, IP, IF, IHC(P) 和 ELISA检测
  • m-IgG2b BP-HRPm-IgGκ BP-HRP 是 Sulfiredoxin 抗体 (B-4) 在 WB and IHC(P) 应用中的首选二抗检测试剂。这些试剂现与Sulfiredoxin 抗体 (B-4) 组合成套装提供。 (请参阅下面的订购信息)。

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関連項目

Sulfiredoxin,也称为Sulfiredoxin-1和染色体20开放阅读框139(C20orf139),是一种细胞质抗氧化蛋白,通过催化减少氧化修饰参与信号传导。它通过将保守的半胱氨酸从亚磺酸还原为亚磺酸来调节过氧化物酶(PRXs),这是一类减少过氧化氢的蛋白质家族。这影响了PRX在其他下游转录因子和激酶信号通路中的作用。Sulfiredoxin蛋白特异性地作用于PRDX1、PRDX2、PRDX3和PRDX4过氧化物酶,但不作用于PRDX5或PRDX6。Sulfiredoxin作为磷酸转移酶和硫醇转移酶起作用,并且在体内广泛表达,在肺、脾、肾和胸腺组织中检测到最高水平。

仅限研究使用。不适用于诊断和治疗用途。

Alexa Fluor® 是Molecular Probes Inc., OR., USA的商标

LI-COR®和 Odyssey® 是LI-COR Biosciences的注册商标

Sulfiredoxin 抗体 (B-4) 参考文献:

  1. 人类硫氧还蛋白在谷胱甘肽化逆转中发挥的新作用。  |  Findlay, VJ., et al. 2006. Cancer Res. 66: 6800-6. PMID: 16818657
  2. 小鼠皮肤肿瘤发生需要肿瘤启动子诱导的磺胺氧化物。  |  Wu, L., et al. 2014. Carcinogenesis. 35: 1177-84. PMID: 24503444
  3. 磺胺火毒素作为过氧化物歧化酶-2 在人类 iPsc 衍生的多巴胺能神经元中的作用  |  Sunico, CR., et al. 2016. Proc Natl Acad Sci U S A. 113: E7564-E7571. PMID: 27821734
  4. 硫氧还蛋白在早期高血糖中参与保护过氧化还原酶免受高氧化的影响。  |  Shi, S., et al. 2017. Exp Cell Res. 352: 273-280. PMID: 28202395
  5. 硫氧还蛋白可能通过Wnt和β-Catenin信号通路促进宫颈癌转移。  |  Lan, K., et al. 2017. Int J Mol Sci. 18: PMID: 28448437
  6. Nrf2激活的磺胺氧化酶的表达有助于尿烷诱导的肺肿瘤发生。  |  Mishra, M., et al. 2018. Cancer Lett. 432: 216-226. PMID: 29906488
  7. 硫氧还蛋白-1通过增强Nrf2/ARE信号的激活,抑制PDGF-BB诱导的血管平滑肌细胞增殖和迁移。  |  Jiang, H., et al. 2022. Int Heart J. 63: 113-121. PMID: 35034915
  8. 芹菜素通过下调皮肤鳞状细胞癌中的硫氧还蛋白表达诱导细胞凋亡。  |  Wang, W., et al. 2022. Oxid Med Cell Longev. 2022: 8172866. PMID: 35965686
  9. 磺胺氧化酶-过氧化物歧化酶 IV 轴在尿烷诱导的非小细胞肺癌中的关键作用  |  Hao, Y., et al. 2023. Antioxidants (Basel). 12: PMID: 36829926
  10. 裂殖酵母硫氧还蛋白Srx1在血红素获取中发挥的新作用。  |  Vahsen, T., et al. 2023. Mol Microbiol. 120: 608-628. PMID: 37644673

订购信息

产品名称产品编号规格价格数量收藏夹

Sulfiredoxin 抗体 (B-4)

sc-373829
200 µg/ml
$316.00

Sulfiredoxin (B-4): m-IgGκ BP-HRP 套装

sc-535316
200 µg Ab; 40 µg BP
$354.00

Sulfiredoxin (B-4): m-IgG2b BP-HRP 套装

sc-549391
200 µg Ab; 10 µg BP
$354.00

I am using Sulfiredoxin (B-4): sc-373829 monoclonal antibody to stain paraffin embedded tissue. Do you recommend antigen retrieval when using this antibody?

Asked by: Randy McDonald
We recommend performing antigen retrieval with sodium citrate buffer (pH 6) and heat. The full protocol can be found here: https://www.scbt.com/scbt/resources/protocols/immunoperoxidase-staining
Answered by: Technical Support
Date published: 2017-02-24
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Rated 5 out of 5 by from Works in IHC(P)Good Sulfiredoxin expression seen in the glandular cells of human thyroid gland samples in IHC.
Date published: 2017-02-03
Rated 5 out of 5 by from Produced beautiful immunoperoxidase cytoplasmicProduced beautiful immunoperoxidase cytoplasmic staining in formalin fixed, paraffin-embedded human thyroid gland tissue. -SCBT QC
Date published: 2015-01-28
Rated 5 out of 5 by from Produced positive Western Blot data of SulfiredoxinProduced positive Western Blot data of Sulfiredoxin expression in non-transfected and human Sulfiredoxin transfected 293T whole cell lysates. -SCBT QC
Date published: 2013-08-18
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Sulfiredoxin 抗体 (B-4) is rated 5.0 out of 5 by 3.
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