Substance P Antibody (SP-DE4-21): sc-58591
- Substance P Antibody (SP-DE4-21) is a mouse monoclonal IgG1, cited in 16 publications, provided at 50 µg/500 µl
- raised against amino acids 1-11 of Substance P of human origin
- recommended for detection of Substance P and protachykinin 1 precursor of mouse, rat and human origin by IF and IHC(P); also reactive with additional species, including and equine and bovine; non cross-reactive with related Tachykinins (human Neurokinin A, Neurokinin B, and Kassinin)
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for Substance P Antibody (SP-DE4-21). This work is in progress.
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Substance P Antibody (SP-DE4-21) is a mouse monoclonal IgG1 antibody specifically designed to target Substance P, an 11-amino-acid neuropeptide belonging to the tachykinin family and also known as neurokinin-1 ligand. Substance P monoclonal antibody (SP-DE4-21) is raised against amino acids 1-11 of human Substance P. Substance P′s structure as an undecapeptide is crucial because its precise amino acid arrangement allows it to bind effectively to the neurokinin-1 (NK1) receptor, mediating essential physiological processes such as pain transmission, inflammation, and vasodilation. Anti-Substance P antibody (SP-DE4-21) reacts with Substance P and the protachykinin 1 precursor in mouse, rat, human, equine, and bovine species when used in immunofluorescence (IF) and immunohistochemistry with paraffin-embedded sections (IHCP), and does not cross-react with related tachykinins like neurokinin A, neurokinin B, or kassinin. Substance P monoclonal antibody (SP-DE4-21) aids researchers in exploring the peptide′s role in neurological and immunological functions, contributing to studies on pain mechanisms and inflammatory diseases. Understanding the structure of Substance P is important because any alterations can affect its interaction with receptors, influencing its biological activity and potential as a therapeutic target. Anti-Substance P antibody (SP-DE4-21) serves as a valuable tool for investigating the complex pathways involving tachykinins and their implications in health and disease.
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Substance P Antibody (SP-DE4-21) References:
- Cancer progression and substance P. | Coveñas, R. and Muñoz, M. 2014. Histol Histopathol. 29: 881-90. PMID: 24535838
- Substance P and its Inhibition in Ocular Inflammation. | Bignami, F., et al. 2016. Curr Drug Targets. 17: 1265-74. PMID: 26477461
- Role of substance P in the cardiovascular system. | Mistrova, E., et al. 2016. Neuropeptides. 58: 41-51. PMID: 26706184
- Neuropeptide substance P and the immune response. | Mashaghi, A., et al. 2016. Cell Mol Life Sci. 73: 4249-4264. PMID: 27314883
- Substance P Regulation in Epilepsy. | Chi, G., et al. 2018. Curr Neuropharmacol. 16: 43-50. PMID: 28474564
- Substance P blocks ethanol-induced hepatotoxicity. | Seo, EJ., et al. 2018. Life Sci. 203: 268-275. PMID: 29730167
- Substance P and pain chronicity. | Zieglgänsberger, W. 2019. Cell Tissue Res. 375: 227-241. PMID: 30284083
- Substance P in cardiovascular diseases - A bioanalytical review. | Feickert, M. and Burckhardt, BB. 2019. Clin Chim Acta. 495: 501-506. PMID: 31103623
- Substance P and fibrotic diseases. | Peng, L., et al. 2019. Neuropeptides. 76: 101941. PMID: 31256921
- The Regenerative Potential of Substance P. | Redkiewicz, P. 2022. Int J Mol Sci. 23: PMID: 35054936
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Substance P Antibody (SP-DE4-21) | sc-58591 | 50 µg/500 µl | $322.00 |