Substance P CAS: 33507-63-0
MF: C63H98N18O13S
MW: 1348
A neurokinin undecapeptide neurotransmitter and neuromodulator.

Substance P (CAS 33507-63-0)

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应用; A neurokinin undecapeptide neurotransmitter and neuromodulator
CAS号码: 33507-63-0
分子量: 1348
分子式: C63H98N18O13S
* 参考分析证明 大量特定数据 (包括水 含量).
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Substance P is a neurokinin neurotransmitter, which is characterized by the C-terminal sequence, Phe-X-Gly-Leu-Met-NH2. Substance P is known to be an important part of endocrine and exocrine gland secretion. In addition, Substance P is essential in smooth muscle contraction, pain, inflammatory response including vasodilation, plasma extravasation and mobilization of immune system cells. Alternate studies suggest that Substance P is a key factor in cancer cell proliferation and that inhibition of this component can induce apoptosis in cancer cells and decrease the steady state of Her2 (Neu) and EGFR. Substance P inhibits the phosphorylation of ERK, which results in a reduction of capsaicin-induced nociception. Substance P is an activator of NK-1R.


参考文献

1. V Euler, U.S. and Gaddum, J.H. 1931. J. Physiol. 72: 74-87. PMID: 16994201
2. Mayordomo, C., et al. 2011. J Cell Physiol. PMID: 21604273
3. Komatsu, T., et al. 2011. Neuropharmacology. [Epub ahead of print]. PMID: 21601581

用法 :
Solubilize the product in an aqueous buffer or DMSO, then run the solution through a sterile filter to achieve a sterile end product.
物理状态 :
Solid
顺序 :
Arg-Pro-Lys-Pro-Gln-Gln-Phe-Phe-Gly-Leu-Met-NH2
溶解度 :
Soluble in water (1 mg/ml), DMSO, and 5% Acetic Acid.
保存 :
Store at -20° C
密度 :
1.43 g/cm3
折射率 :
n20D 1.66
IC50 :
Neurokinin 1 receptor: IC50 = 0.12 nM (human); Neurokinin 3 receptor: IC50 = 125 nM (human)
Ki 数据 :
Neurokinin 1 receptor: Ki= 1.1 nM (rat)
仅供科研使用。不可用于诊断或治疗。
德国水公害等级 :
3
RTECS :
WM2660000
PubChem CID :
36511
默克索引 :
14: 8863
MDL 号码 :
MFCD00076780
EC号码 :
251-545-8
Beilstein 注册 :
5153552
SMILES :
CC(C)CC(C(=O)NC(CCSC)C(=O)N)NC(=O)CNC(=O)C(CC1=CC=CC=C1)NC(=O)C(CC2=CC=CC=C2)NC(=O)C(CCC(=O)N)NC(=O)C(CCC(=O)N)NC(=O)C3CCCN3C(=O)C(CCCCN)NC(=O)C4CCCN4C(=O)C(CCCN=C(N)N)N

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