SSSCA1 Antibody (NB-C27): sc-135570
- SSSCA1 Antibody (NB-C27) is a mouse monoclonal IgG2b κ provided at 100 µg/ml
- raised against recombinant SSSCA1 protein of human origin
- recommended for detection of SSSCA1 of mouse, rat and human origin by WB, IP and ELISA
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for SSSCA1 Antibody (NB-C27). This work is in progress.
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SSSCA1 Antibody (NB-C27) is a mouse monoclonal IgG2b antibody that detects SSSCA1 in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), and enzyme-linked immunosorbent assay (ELISA). SSSCA1, also known as Sjogren syndrome/scleroderma autoantigen 1 or p27, is a 199 amino acid protein that plays a crucial role in mitosis, functioning as a centromere-associated protein. SSSCA1′s importance lies in its potential to induce anti-centromere antibodies, which are significant in the context of autoimmune diseases such as scleroderma and Sjogren′s syndrome. Additionally, SSSCA1 undergoes phosphorylation in response to DNA damage, mediated by the ATM or ATR pathways, highlighting SSSCA1′s role in cellular stress responses and genomic stability. The gene encoding SSSCA1 is located on human chromosome 11, a region that is home to over 1,400 genes and is implicated in various genetic disorders, including Jervell and Lange-Nielsen syndrome and Jacobsen syndrome. Anti-SSSCA1 antibody (NB-C27) is an essential tool for researchers investigating the molecular mechanisms underlying these conditions and the broader implications of centromere function in cell division and disease.
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
SSSCA1 Antibody (NB-C27) | sc-135570 | 100 µg/ml | $339.00 |