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SREBP-2 Antibody (C-6) - Western Blotting - Image 354084 — SREBP-2 抗体 (C-6): sc-271615. MOLT-4 (A), RAW 264. 7 (B), Ramos (C), HeLa (D) 和 IMR-32 (E) 全细胞裂解液中 SREBP-2 表达的 Western 印迹分析.

SREBP-2 抗体 (C-6): sc-271615. MOLT-4 (A), RAW 264. 7 (B), Ramos (C), HeLa (D) 和 IMR-32 (E) 全细胞裂解液中 SREBP-2 表达的 Western 印迹分析.

SREBP-2 抗体 (C-6): sc-271615

5.0(2)

寫評論提問

说明书

SREBP-2抗体(C-6)是小鼠单克隆IgG_2a κ, 在12篇文献中引用，规格为200 µg/ml
免疫human物种的SREBP-2的氨基酸812-975
推荐用于 mouse, rat 和 human 来源的SREBP-2 WB, IP, IF, IHC(P) 和 ELISA检测
看 SREBP-2 (1C6): sc-13552，可查看有标记的 SREBP-2 抗体，包括AC, HRP, FITC, PE, Alexa Fluor^® 488, 594, 647, 680 和 790
m-IgG Fc BP-HRP是SREBP-2 Antibody (C-6) 适用于 WB 和 IHC(P) 应用。的首选辅助检测试剂。该试剂现与SREBP-2 Antibody (C-6) 搭配使用（请参阅下面的订购信息）。

查看产品引用文献(12)

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SREBP-2 抗体 (C-6) 参考文献:

SREBP-2在人类肠道细胞中负调控FXR依赖的FGF19转录。 | Miyata, M., et al. 2014. Biochem Biophys Res Commun. 443: 477-82. PMID: 24321096
SREBP-2通过在前列腺癌中激活c-Myc的转录来促进干细胞样特性和转移。 | Li, X., et al. 2016. Oncotarget. 7: 12869-84. PMID: 26883200
SREBP-1c的表达需要SREBP-2介导的小鼠肝脏中LXR的固醇配体的产生。 | Rong, S., et al. 2017. Elife. 6: PMID: 28244871
Aβ 通过抑制 Akt 来抑制 SREBP-2 的激活。 | Mohamed, A., et al. 2018. J Lipid Res. 59: 1-13. PMID: 29122977
SREBP‑2 表达模式导致蒙古沙鼠易患高胆固醇血症。 | Li, C., et al. 2018. Mol Med Rep. 17: 3288-3296. PMID: 29257228
SREBP-2驱动的人类SND1癌基因的转录激活。 | Armengol, S., et al. 2017. Oncotarget. 8: 108181-108194. PMID: 29296233
SREBP-2 通过促进破骨细胞生成和乳腺癌转移加重乳腺癌相关的骨质溶解。 | Jie, Z., et al. 2019. Biochim Biophys Acta Mol Basis Dis. 1865: 115-125. PMID: 30394316
内源性氧固醇对胆固醇平衡的羟基化位点特异性和生产依赖性影响：对SREBP-2和LXR的影响。 | Saito, H., et al. 2023. J Biol Chem. 299: 102733. PMID: 36423680
木犀草素通过调节ACAT-2、PPARα、SREBP-2蛋白和氧化应激来减轻大鼠的糖尿病性血脂异常。 | Shehnaz, SI., et al. 2023. Appl Biochem Biotechnol. 195: 4893-4914. PMID: 37103741
胆固醇耗竭通过 SREBP-2 信号激活肝星状细胞。 | Vijayan, N. and Perumal, MK. 2024. J Cell Physiol.. PMID: 39535453

种属	基因名称	基因ID	染色体位置	亚型（mRNA）登录号	蛋白质登录号	OMIM™ 号码
Human	SREBF2	Entrez Gene ID: 6721	22q13.2	XM_006724310, XM_011530347, XM_017028921, XM_017028922, NM_004599	UniProt ID: Q12772	600481
Mouse	Srebf2	Entrez Gene ID: 20788	15 E1	XM_006520685, NM_033218	UniProt ID: Q3U1N2	N/A

订购信息

产品名称	产品编号	规格	价格	数量	收藏夹
SREBP-2 抗体 (C-6)	sc-271615	200 µg/ml	$322.00
SREBP-2 (C-6): m-IgG Fc BP-HRP 套装	sc-540254	200 µg Ab; 10 µg BP	$361.00

Why do your WBlott samples (Data sh.) as well as the above citations (Liu et al) show a 55/68 kDa mark if the antibody was performed to the C-terminal part of the protein ( not present in the mature form of SREBP) ??? Isn´t that inespecific??

Asked by: tesl

Thank you for your question. There are known cleavage and degradation products for SERBP-2 that run as low as 55kDa, so it's possible to see signal for this protein ranging from that size and up to mature form around 68-70kDa and pre-cursor around 125kDa. It is very dependent on your samples and the status of the protein in your samples.

Answered by: Tech Service

Date published: 2020-01-16

I am using SREBP-2 (C-6): sc-271615 monoclonal antibody to stain paraffin embedded tissue. Do you recommend antigen retrieval when using this antibody?

Asked by: Germaine

We recommend performing antigen retrieval with sodium citrate buffer (pH 6) and heat. The full protocol can be found here: https://www.scbt.com/scbt/resources/protocols/immunoperoxidase-staining

Answered by: Technical Support

Date published: 2017-02-24

Rated 5 out of 5 by CJ from Beautiful immunoperoxidase cytoplasmic stainingBeautiful immunoperoxidase cytoplasmic staining in formalin fixed, paraffin-embedded human oral mucosa tissue. -SCBT QC

Date published: 2015-03-26

Rated 5 out of 5 by TS from Great antibody for Western BlotGreat antibody for Western Blot, nice signal on LNCaP whole cell lysate. -SCBT QC

Date published: 2015-02-02

SREBP-2 抗体 (C-6) is rated 5.0 out of 5 by 2.

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SREBP-2 抗体 (C-6): sc-271615

SREBP-2 抗体 (C-6) 参考文献:

優選的 SREBP-2 抗體是 SREBP-2 抗體 (1C6): sc-13552.

SREBP-2 抗体 (C-6)

SREBP-2 (C-6): m-IgG Fc BP-HRP 套装

Why do your WBlott samples (Data sh.) as well as the above citations (Liu et al) show a 55/68 kDa mark if the antibody was performed to the C-terminal part of the protein ( not present in the mature form of SREBP) ??? Isn&acute;t that inespecific??

I am using SREBP-2 (C-6): sc-271615 monoclonal antibody to stain paraffin embedded tissue. Do you recommend antigen retrieval when using this antibody?

Why do your WBlott samples (Data sh.) as well as the above citations (Liu et al) show a 55/68 kDa mark if the antibody was performed to the C-terminal part of the protein ( not present in the mature form of SREBP) ??? Isn´t that inespecific??