Date published: 2025-9-6

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SREBP-2 抗体 (C-6): sc-271615

5.0(2)
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说明书
  • SREBP-2抗体(C-6)是小鼠单克隆IgG2a κ, 在11篇文献中引用,规格为200 µg/ml
  • 免疫human物种的SREBP-2的氨基酸812-975
  • 推荐用于 mouse, rat 和 human 来源的SREBP-2 WB, IP, IF, IHC(P) 和 ELISA检测
  • 看 SREBP-2 (1C6): sc-13552,可查看有标记的 SREBP-2 抗体,包括AC, HRP, FITC, PE, Alexa Fluor® 488, 594, 647, 680 和 790
  • m-IgG Fc BP-HRP 是 SREBP-2 抗体 (C-6) 在 WB and IHC(P) 应用中的首选二抗检测试剂。该试剂现与SREBP-2 抗体 (C-6) 组合成套装提供。 (请参阅下面的订购信息)。

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低密度脂蛋白(LDL)受体介导胆固醇携带脂蛋白的内吞作用,从而控制细胞和血浆中的胆固醇水平。 LDL受体基因的转录由5'侧翼区中的10个碱基对序列控制,该序列被称为固醇调节元件1(SRE-1)。当细胞内固醇储存耗尽时,该元件被激活,基因被转录,细胞对LDL的摄取增加。已经鉴定出一组SRE结合蛋白(SREBP),包括两个碱性螺旋-环-螺旋-亮氨酸拉链(bHLH-Zip)转录因子,分别称为SREBP-1和SREBP-2。 SREBP-1和SREBP-2在体外对SRE-1具有相同的特异性,并以相同的方式激活含有SRE-1的报告基因的转录。

仅限研究使用。不适用于诊断和治疗用途。

订购信息

产品名称产品编号规格价格数量收藏夹

SREBP-2 抗体 (C-6)

sc-271615
200 µg/ml
$316.00

SREBP-2 (C-6): m-IgG Fc BP-HRP 套装

sc-540254
200 µg Ab; 10 µg BP
$354.00

Why do your WBlott samples (Data sh.) as well as the above citations (Liu et al) show a 55/68 kDa mark if the antibody was performed to the C-terminal part of the protein ( not present in the mature form of SREBP) ??? Isn´t that inespecific??

Asked by: tesl
Thank you for your question. There are known cleavage and degradation products for SERBP-2 that run as low as 55kDa, so it's possible to see signal for this protein ranging from that size and up to mature form around 68-70kDa and pre-cursor around 125kDa. It is very dependent on your samples and the status of the protein in your samples.
Answered by: Tech Service
Date published: 2020-01-16

I am using SREBP-2 (C-6): sc-271615 monoclonal antibody to stain paraffin embedded tissue. Do you recommend antigen retrieval when using this antibody?

Asked by: Germaine
We recommend performing antigen retrieval with sodium citrate buffer (pH 6) and heat. The full protocol can be found here: https://www.scbt.com/scbt/resources/protocols/immunoperoxidase-staining
Answered by: Technical Support
Date published: 2017-02-24
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Rated 5 out of 5 by from Beautiful immunoperoxidase cytoplasmic stainingBeautiful immunoperoxidase cytoplasmic staining in formalin fixed, paraffin-embedded human oral mucosa tissue. -SCBT QC
Date published: 2015-03-26
Rated 5 out of 5 by from Great antibody for Western BlotGreat antibody for Western Blot, nice signal on LNCaP whole cell lysate. -SCBT QC
Date published: 2015-02-02
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SREBP-2 抗体 (C-6) is rated 5.0 out of 5 by 2.
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