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Sorafenib (CAS 284461-73-0)

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Alternate Names:
Sorafenib is also known as Sorafenibum.
Application:
Sorafenib is an inhibitor of Raf-1 and B-RAF as well as several tyrosine kinases. Sorafenib also inhibits tumor angiogenesis by inducing tumor cell apoptosis.
CAS Number:
284461-73-0
Purity:
≥98%
Molecular Weight:
464.82
Molecular Formula:
C21H16ClF3N4O3
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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Sorafenib is a RAF kinase inhibitor which suppresses ERK phosphorylation. Studies indicate that Sorafenib induces c-Raf phosphorylation at both Ser-43 and Ser-259. When combined with vitamin K1, phosphorylation is increased at these serine residues. Sorafenib also induces the phosphorylation of PKA. In addition, Sorafenib induces c-Met phosphorylation at Tyr-1349, which consequently induces PI3K-Akt phosphorylation. Studies determined that Sorafenib inhibits other kinases such as Flk-1 (VEGFR2), PDGFR (platelet-derived growth factor receptor), Flt-3/Flk-2 (FLT3), Ret, and c-Kit. Sorafenib is an inhibitor of Raf-1, Raf-B, PDGFR-betaand Flt-4. Its ability to affect the Raf/Mek/Erk pathway makes it useful in cancer research studies. Sorafenib is also known as Sorafenibum, BAY 43-9006, and 4-[4-[[[[4-chloro-3-(trifluoromethyl)phenyl]amino]carbonyl]amino]phenoxy]-N-methyl-2-pyridinecarboxamide.


Sorafenib (CAS 284461-73-0) References

  1. A phase I clinical and pharmacokinetic study of the Raf kinase inhibitor (RKI) BAY 43-9006 administered in combination with doxorubicin in patients with solid tumors.  |  Richly, H., et al. 2003. Int J Clin Pharmacol Ther. 41: 620-1. PMID: 14692720
  2. Omega-carboxypyridyl substituted ureas as Raf kinase inhibitors: SAR of the amide substituent.  |  Khire, UR., et al. 2004. Bioorg Med Chem Lett. 14: 783-6. PMID: 14741289
  3. BAY 43-9006 exhibits broad spectrum oral antitumor activity and targets the RAF/MEK/ERK pathway and receptor tyrosine kinases involved in tumor progression and angiogenesis.  |  Wilhelm, SM., et al. 2004. Cancer Res. 64: 7099-109. PMID: 15466206
  4. Sorafenib.  |  Rini, BI. 2006. Expert Opin Pharmacother. 7: 453-61. PMID: 16503817
  5. Sorafenib blocks the RAF/MEK/ERK pathway, inhibits tumor angiogenesis, and induces tumor cell apoptosis in hepatocellular carcinoma model PLC/PRF/5.  |  Liu, L., et al. 2006. Cancer Res. 66: 11851-8. PMID: 17178882
  6. c-Met-Akt pathway-mediated enhancement of inhibitory c-Raf phosphorylation is involved in vitamin K1 and sorafenib synergy on HCC growth inhibition.  |  Carr, BI., et al. 2011. Cancer Biol Ther. 12: 531-8. PMID: 21734462
  7. A model of neuropathic pain induced by sorafenib in the rat: Effect of dimiracetam.  |  Di Cesare Mannelli, L., et al. 2015. Neurotoxicology. 50: 101-7. PMID: 26254739
  8. Sorafenib for Advanced and Refractory Desmoid Tumors.  |  Gounder, MM., et al. 2018. N Engl J Med. 379: 2417-2428. PMID: 30575484
  9. The microenvironmental and metabolic aspects of sorafenib resistance in hepatocellular carcinoma.  |  Xia, S., et al. 2020. EBioMedicine. 51: 102610. PMID: 31918403
  10. The mechanisms of sorafenib resistance in hepatocellular carcinoma: theoretical basis and therapeutic aspects.  |  Tang, W., et al. 2020. Signal Transduct Target Ther. 5: 87. PMID: 32532960
  11. Current status of sorafenib nanoparticle delivery systems in the treatment of hepatocellular carcinoma.  |  Kong, FH., et al. 2021. Theranostics. 11: 5464-5490. PMID: 33859758
  12. Cholesterol sensor SCAP contributes to sorafenib resistance by regulating autophagy in hepatocellular carcinoma.  |  Li, D., et al. 2022. J Exp Clin Cancer Res. 41: 116. PMID: 35354475
  13. Retraction Note: Combination of sorafenib and gadolinium chloride (GdCl3) attenuates dimethylnitrosamine(DMN)-induced liver fibrosis in rats.  |  Liu, C., et al. 2022. BMC Gastroenterol. 22: 421. PMID: 36109709
  14. Effect of Novel AKT Inhibitor Vevorisertib as Single Agent and in Combination with Sorafenib on Hepatocellular Carcinoma in a Cirrhotic Rat Model.  |  Kurma, K., et al. 2022. Int J Mol Sci. 23: PMID: 36555845

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

Sorafenib, 5 mg

sc-220125
5 mg
$57.00

Sorafenib, 50 mg

sc-220125A
50 mg
$100.00

Sorafenib, 500 mg

sc-220125B
500 mg
$250.00

For in vivo use, a lot of literature has stated sorafenib needs to be dissolved in a cremaphor solution (one example is 30% (w/v) cremophor, 30% (w/v) PEG 400, 10% ethanol, and 10% glucose). Do you have any information about this solution for solubility.

Asked by: avila
Thank you for your question. Sorafenib (CAS 284461-73-0) sc-220125 is soluble in DMSO (~20 mg/ml), Hot Methanol, DMF (~20 mg/ml), 1:2 solution of DMSO:PBS(PH 7.2 ) (~0.3 mg/ml), 100% ethanol, and ethyl acetate. If you require additional information on this compound please get in touch with technical service.
Answered by: Tech Support Europe
Date published: 2022-01-10

Does a solution of Sorafenib in DMSO interact with DMEM or Fetal Bovine Serum? and If not, what is the storage conditions for such solution (Sorafenib plus DMEM plus FBS)? Thanks a lot

Asked by: Ahmed Abdelmageed Saad
Thank you for your question. We have not tested this, so we cannot comment on the interaction with DMEM or FBS. We always recommend using solutions the same day they are made. However, if necessary to make ahead of time, solutions should be stored at -20ºC.
Answered by: Technical Service
Date published: 2018-11-14

What is the stability of Sorafenib (sc-220125) at room temperature? and what is the perfect transportation condition?

Asked by: Ahmed Abdelmageed Saad
Thank you for your question. We transport Sorafenib (sc-220125) at room temperature and we don’t recommend storing at room temperature for longer than 2 weeks.
Answered by: Technical Support
Date published: 2018-11-14

Could you please tell me what the storage conditions are after solubilisation in DMSO and how long can I store them? 

Asked by: two2igm05
Thank you for your question. Sorafenib, sc-220125, can be stored for 6 months at -80℃ in solvent.
Answered by: TechService7
Date published: 2019-08-12

What is the solubility of this product?

Asked by: hawkeye11
Thank you for you question. This product is soluble in DMSO (~20 mg/ml), warm methanol (<1 mM), 1:2 solution of PBS:DMSO (.3 mg/ml), and in ethanol. Please contact Technical Service if you have further questions concerning this product.
Answered by: Tech Service 9
Date published: 2018-08-07

I would like to ask a quotation on the following drug. CAS number: 284461-73-0 Cat number: sc-220125A Name: Sorafenib (pure) Quantity: 100mg I would appreciate if you could include the shipping costs in the quotation Regards Alexandra Alvarez

Asked by: lexalfer
Thank you for your inquiry with Santa Cruz Biotechnology. For an accurate quote with pricing and shipping information, please contact one of our authorized distributors in Singapore. You can find their contact information here: https://www.scbt.com/scbt/resources/distributors
Answered by: Tech Service
Date published: 2016-10-05
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Rated 5 out of 5 by from Great inhibitorSorafenib inhibited cell proliferation as expected. Great performance!
Date published: 2022-07-28
Rated 5 out of 5 by from Shows strong inhibition of Ras/ERK pathway at 1uMShows strong inhibition of Ras/ERK pathway at 1uM, leading to decreased migration in C6 cells.
Date published: 2015-04-08
Rated 5 out of 5 by from A lack of phosphorylation of the ERK proteinA lack of phosphorylation of the ERK protein was observed by WB using SK-MEL-28 cells post treatment with Sorafenib. -SCBT QC
Date published: 2015-03-23
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Sorafenib | CAS 284461-73-0 is rated 5.0 out of 5 by 3.
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